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SAT0141 Vitamin D Deficiency is A Risk Factor for Carotid Atherosclerosis in Women with Rheumatoid Arthritis
  1. E.-K. Park1,
  2. S.-G. Lee1,
  3. G.-T. Kim2,
  4. J.-H. Lee3,
  5. S.-H. Baek3,
  6. J.-W. Lee4
  1. 1Rheumatology, Pusan National University Hospital
  2. 2Rheumatology, Kosin University College of Medicine
  3. 3Internal Medicine, Ilsin Christian Hospital
  4. 4Internal Medicine, Busan St. Mary's Hospital, Busan, Korea, Republic Of

Abstract

Background Although there is increasing evidence that low serum 25-hydroxy vitamin D (25-OHD) is associated with a higher frequency of cardiovascular diseases (CVDs) in the general population, little attention has been given to the relationship between vitamin D deficiency and atherosclerosis in patients with rheumatoid arthritis (RA).

Objectives The present study aimed to investigate whether vitamin D deficiency is a potential risk factor for carotid atherosclerosis in patients with (RA).

Methods With a cross-sectional design, we recruited 60 consecutive female RA patients without previous CVDs between September 2013 and December 2013 at the outpatient rheumatology clinic of a tertiary referral centre in South Korea. Carotid intima media thickness (CIMT) was measured using high-resolution ultrasonography (Philips HD15, Bothwell, WA, USA) and QLAB's IMT-quantification software plug-in (Philips Healthcare, DA Best, The Netherlands) was used to enhance the consistency and reliability of CIMT measurement. Serum 25-OHD levels were assessed by radioimmunoassay. Stepwise multivariable linear regression models were used to evaluate the association between serum 25-OHD levels and CIMT.

Results Mean (SD) age and disease duration were 56.0 (11.2) and 5.9 (4.9) years, respectively. Median 25-OHD levels (IQR) was 14.0 (11.0-20.7) ng/mL and 74% of patients had vitamin D deficiency (<20ng/mL). Mean (SD) CIMT was 0.58 (0.08) mm and 24 (48%) RA patients had abnormal CIMT (≥6 mm). Compared to RA patients with normal CIMT (<6mm), those with abnormal CIMT (≥6 mm) were older and had longer disease duration, lower serum 25-OHD levels and high density lipoprotein (HDL) and higher disease activity score (DAS) 28 and Korean version of health assessment questionnaire (K-HAQ) score. In univariable analyses, lower serum 25-OHD levels and HDL, older age, and higher DAS28 and K-HAQ scores were associated with increased CIMT (Table 1), while disease duration, blood pressure, triglyceride, low density lipoprotein and Homeostatic model assessment - insulin resistance showed no association with CIMT. Serum 25-OHD levels remains statistically significant in multivariable regression models after adjusting confounding factors (Table 1).

Table 1.

Linear regression models evaluating the association between serum vitamin D levels and carotid intima media thickness

Conclusions Our data suggests that vitamin D deficiency is a risk factor for subclinical atherosclerosis in female patients with RA. Larger prospective studies are needed to confirm our observation.

Acknowledgements None

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.1510

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