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FRI0159 Progression of Early Axial Spondyloarthritis to Ankylosing Spondylitis after 6-Years Follow-Up
  1. A. Bochkova1,
  2. A. Levshakova2,
  3. O. Rumyantseva1,
  4. A. Smirnov1,
  5. S. Erdes1
  1. 1Nasonova Research Institute of Rheumatology
  2. 2Research Centre of Neurology, Moscow, Russian Federation

Abstract

Background Early axial spondyloarthritis may resolve spontaneously, remain undifferentiated, or progress to ankylosing spondylitis or another spondyloarthritis. There are a need for improving the early diagnosis of ankylosing spondylitis (AS) and other spondyloarthritis (SpA).

Objectives To assess the level of agreement between a SpA at baseline and 6 years later in cohort of patients with recent-onset axial spondyloarthritis.

Methods Patients with duration of inflammatory back pain less than 2 years (between 2006 and 2008) were included. Patients followed-up in our department during about 6 years. And in patients who not followed-up in our department physician was contacted by phone to determine the final diagnosis.

Results Diagnosis at baseline and 6 years later was known for 50 patients. At baseline all patients were diagnosed as axial SpA by ESSG, mean age 23.9 years, mean duration IBP 17 month, MRI sacroiliitis - 44% patients, HLA B27 positive were 96% patients, and peripheral arthritis/enthesitis have 28% patients. Mean follow-up was 5.9 years, and in the end of 2013 year 56% patients have AS; 20% patients have nr-axSpA (ASAS2009): 1 patient associated with psoriasis, 1 patients associated with IBD; 4% patients have peripheral SpA (ASAS 2012), 20% patients were healthy or have full remission. At baseline rise erythrocyte sedimentation rate (ESR) observed more frequently in patients with outcome to AS. Sacroiliitis is seen on MRI was a good predictor of future AS (likelihood ratio [LR] 3,0; specificity 67,6%) but not HLA–B27 positivity (LR 1,0; specificity 6,7%)

Conclusions Only 56% nr-axSpA patients became AS after 6 years follow-up. MRI sacroiliitis and high erythrocyte sedimentation rate were predictors of future ankylosing spondylitis.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3324

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