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FRI0151 Correlations between Sleep Disturbance and Specific Disease Parameters in Ankylosing Spondylitis
  1. W. Hamdi,
  2. I. Cherif,
  3. I. Zouch,
  4. D. Kaffel,
  5. M.M. Kchir
  1. Rheumatology, Kassab Institut, Tunis, Tunisia

Abstract

Background Sleep disturbance is a frequent feature of chronic inflammatory rheumatisms particularly in Ankylosing Spondylitis (AS).

Objectives The aim of this study was to evaluate sleep quality and its relationship with specific disease parameters in patients with AS.

Methods We conduct a cross sectional prospective study including patients with AS fulfilling the New York modified criteria. The MOS sleep Questionnaire was used for the assessment of sleep disturbance. It is a 12-item questionnaire exploring 6 domains of sleep: sleep adequacy, sleep disturbance, sleep quantity, daytime sleepiness, snoring and shortness of breath or headache. It leads to two sleep problem indexes (SP1 and SP2). Pain was evaluated by VAS. Disease activity was evaluated by BASDAI, ASDAS ESR and ASDAS CRP, functional impairment and quality of life by ASQOL and BASFI and structural damage by BASRI and mSASS.

Results Fifty patients with AS patients were included. The mean age was 42±12,1 years (range 18 to 65) with a male to female ratio about 3,5. The mean body mass index (BMI) was 24,8±4,1 kg/m2. The mean disease duration was 9,8±8,1years [range 0,5 to 39]. The mean duration of morning stiffness was 36±35 minutes [range 0to 120] and the mean awakening number was 1,52±1,44 times per night. The mean VAS pain was 49,85±25,17 [range 0,5 to 90]. The mean BASDAI was 47±24,56 [range 0 to 100]. The mean ASDASESR was 3±1,14 [range 1 to 5,1] and the mean ASDASCRP was 2,9±1,03 [range 1to 5]. The mean BASFI was 48,3±29,8 [range 0 to 98]. The mean ASQOL was 4,7±5,38 [range to]. The mean BASRI was 7,5±3,27. The mean m SASSS was 10,52±13,38. The mean ESR was 34,9±21,9 [4-84] and the mean CRP was 18,9±17 [3-73].

The results of the MOS sleep questionnaire and the correlations of its different items with disease specific parameters are presented in Table 1.

Table 1.

Correlation between disease parameters and items of MOS sleep questionnairein AS

Conclusions Our study showed that the poor sleep quality in AS is especially associated with disease activity, pain biologic inflammation, poor quality of life but not with structural damage

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.6006

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