Since 2006, the OMERACT RA Flare Group has been working together to define and measure RA flare to facilitate research and improve clinical practice. We are an international collaboration of rheumatology researchers, clinicians, patients, measurement specialists, and industry partners. Using multiple strategies including literature reviews, patient focus groups, patient and provider Delphi exercises, data from observational studies and consensus voting at OMERACT conferences, we developed a consensus-based definition for serious inflammatory RA flares and identified relevant domains to measure. This lecture will provide an overview of our recent work and present initial findings from ongoing efforts to validate an initial set of items for an RA Flare tool that can precisely and reliably measure flare severity across patients, providers and settings. Items provide an expanded assessment of disease worsening (beyond the traditional RA core set) from the patient's perspective. Item responses from several large clinical and observational trials in North American and Europe are combined with clinical data to help identify, characterize and quantify RA flares from multiple perspectives and across relevant domains. Both traditional and modern psychometric approaches are being used to refine the final OMERACT RA Flare Questionnaire prior to release for widespread use.
Disclosure of Interest None declared