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THU0547 Association of Asymptomatic Hyperuricemia and Endothelial Dysfunction in Psoriatic Arthritis
  1. S.E. Ibrahim1,
  2. A. Helmy1,
  3. T. Youssef2,
  4. M. Hassan2,
  5. N. Farouk2
  1. 1Department of Rheumatology, Ain Shams University
  2. 2Faculty of Medicine, Ain Shams University, Cairo, Egypt

Abstract

Background Cardiovascular disease is an increasingly recognized contributor to excess morbidity and mortality in psoriatic arthritis (PsA). Atherosclerosis is a multifocal, immune-inflammatory disease affecting the medium and large arteries. There is growing evidence that, in addition to traditional risk factors, vascular wall inflammation plays a key role in the pathogenesis of vascular diseases and atherosclerosis.

Objectives To examine the prevalence of suclinical atherosclerosis in patients with psoriatic arthritis to emphasize the potential role of serum uric acid on endothelial dysfunction, as an early predictor of atherosclerosis in psoriatic arthritis patients.

Methods This study included 60 PsA patients as well as 60 age and sex matched healthy controls. Assay of serum uric acid, interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) was done for all patients and controls. Patients were subjected to psoriasis area severity index (PASI) and assessment of disease activity. Patients and controls underwent brachial flow-mediated dilatation (FMD) assessment by color duplex sonography to determine endothelial dysfunction as well as extracranial carotid arteries assessment by high-resolution B-mode ultrasound to measure the common carotid intima-media thickness (CIMT) and the detection of atheromatous plaques.

Results PsA patients have a high significant difference in CIMT, FMD of the brachial artery and mean levels of serum uric acid compared to healthy controls (p<0.001). PsA patients with hyperuricemia have a high significant difference in CIMT and FMD of the brachial artery than those with normal serum uric acid. Serum uric acid levels showed a high significant positive correlation with each of CIMT, disease duration, markers of inflammation (ESR, CRP, IL-6, sICAM-1),disease activity score in 28 joints (DAS 28) and PASI (r =0.71, 0.893, 0.956, 0.858, 0.853, 0.877, 0.907, 0.847, respectively, as p<0.001). A high significant negative correlation was found betweenserum uric acid levels and FMD of the brachial artery as r = _0.634, p<0.001.

Conclusions Patients with PsA have a high prevalence of subclinical atherosclerosis dependent on serum uric acid, suggesting that chronic systemic inflammation and endothelial dysfunction appear to be the link between asymptomatic hyperuricemia and atherosclerosis. Therefore, proper control of serum uric acid may play a preventive role in the development of atherosclerosis in PsA patients.

References

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  2. Contessa C, Ramonda R, Lo Nigro A, Modesti V, Lorenzin M, Puato M, et al. Subclinical atherosclerosis in patients with psoriatic arthritis: a case-control study. Preliminary data. Reumatismo 2009;25:298–305.

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Disclosure of Interest : None declared

DOI 10.1136/annrheumdis-2014-eular.2324

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