Osteoarthritis (OA) is a heterogeneous condition in which various symptoms culminate via different pathways in a common clinically characteristic pathology. The disease involves not only cartilage but the whole joint, including subchondral bone, synovial tissue, menisci (in the case of the knee), the capsule, ligaments, and muscles. OA slowly progresses and increases in prevalence and severity with age. To understand the complex inter-relationship between the different disease mechanisms, joint tissues, and body systems, studying OA in animal models is necessary. Numerous animal models of OA have been developed in lots of different species, including horses, sheep, dogs, rats, and mice. Several factors should be taken into account when choosing a specific model. This presentation addresses several of these aspects and describes the generally accepted smaller and larger animal models of OA and their translation to clinic practice.
Disclosure of Interest None declared
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