Background Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by paroxysmal episodes of fever and serosal inflammation. The classical presentation is fever and severe recurrent abdominal pain due to serositis that lasts for one to three days and the resolves spontaneously. Some people experience chills prior to the onset of fever.
Objectives In this study, we aimed to determine whether the chills is the predictor factor or not for the severity score in patients with FMF.
Methods Consecutively 57 patients diagnosed with FMF were recruited for this cohort study, and the patients were classified according to the Tel-Hashomer Severity Score. Pearson correlation analysis was made to find the relationships between disease severity score and clinical features of the patients. A linier regression analysis was performed to identify the possible predictors of the FMF severity score.
Results The mean age was 30.72±9.99 years, 54.4% was male and 45.6% was female. There was a mean period of 16.87±10.59 years from disease onset to diagnosis. Delayed in the diagnosis time was 13.10±11.00. Patients' clinical features included peritonitis (96.5%), fever (82.5%), arthritis (38.6%), pleuritis (14%), chills (35.1%), and erysipelas-like erythema (15.8%). Thirty three percent of the patients had a history of appendicitis. Amyloidosis was not remarkably frequent in our patients (1.8%). Genetic analysis of 57 patients revealed that M694V was the most frequent mutation (70.2%), followed by M680I (21%) and V726A (21.2%). In Pearson correlation analysis chills were correlated with fever (r=0.339, p=0.01), and a history of appendicitis (r=0.416, p=0.001). Linier regression analysis showed that chill is the independent predictor factor of the FMF severity score (Adjusted r2=0.414, Beta=0.462, Std error=2.127, p=0.003).
Conclusions Our study showed that chills would be a predictor factor to demonstrate the FMF severity score. Future large-scale multicenter randomized controlled studies are needed and warranted to clarify our results.
Disclosure of Interest : None declared