The conjugation of ubiquitin to proteins is involved in the regulation of many processes. Although ubiquitination was initially identified as a signal that leads to proteasome-mediated degradation of the target protein, it has become clear that attachment of ubiquitin can lead to different outcomes depending on the type of this attachment. Aberrant ubiquitination promotes numerous disease states, but the mechanisms by which the ubiquitin system regulates cellular signaling and pathogenesis remain largely unknown. In this presentation I will highlight recent basic science advances in the field of ubiquitin research and the role of ubiquitination in cellular signaling, with a focus on enzymes and specific pathways related to arthritis. I will also discuss how deeper insights into the versatility of ubiquitination brings new excitement and hope for further successful drug development.
Disclosure of Interest None declared