Background Interstitial Cystitis (IC) has been suggested to have an underlying autoimmune mechanism and to be associated with Systemic Lupus Erythematosus (SLE) and Sjögren's syndrome (SS). In these conditions, lower urinary tract symptoms (LUTS) associated with overactive bladder (OAB) may be present since early stages of disease and be interpreted by patients as normal.
Objectives To compare OAB symptom bother (SB) and health-related quality of life (HRQL) between healthy controls and patients with SLE and SS.
Methods In a cross-sectional cohort study, we applied a validated questionnaire assessing LUTS and HRQL, the OAB questionnaire short form (OABq-SF, range 0-100), to SLE/SS patients followed in a hospital outpatient clinic and to patients from a primary health care centre that had none of the diseases. We further collected information on possible confounding variables. Group comparisons by Mann-Whitney and chi-square test and multiple regression analyses were conducted. Based on literature findings, we defined a SB score greater than 20/100 and a HRQL score lower than 90/100, as clinically meaningful.
Results We included 203 controls and 93 rheumatic patients (64 SLE, 29 SS). Both groups had similar characteristics except for gender distribution, anti-depressant and corticosteroid consumption (Table 1). OABq-SF SB scores were greater and HRQL scores were lower in the SLE/SS group, compared to controls (p<0.0001 and p=0.0002, respectively). SLE/SS patients had higher proportions of SB score ≥20 (OR 3.1, 1.9-5.2) and HQRL≤90 (OR 2.4, 1.4-4.2). The same differences were seen for the SLE/SS subgroups separately. Multivariate logistic regression revealed that SLE/SS patients were more likely to have a SB score greater than 20/100 (OR 2.72, 1.55-4.79) and a HRQL score lower than 90/100 (OR 1.90, 1.01-3.56), adjusting for age, sex, diuretics, recent urinary infection (≤3 months) and antidepressants.
Conclusions Patients with SLE/SS had higher OAB symptom scores and lower HRQL scores compared to controls, using a validated questionnaire. They were also more likely to have a clinically meaningful score, suggesting that OAB and IC might be, indeed, more frequent in these patients.
Disclosure of Interest : None declared
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