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THU0022 Systemic Lupus Erythematosus Increases Risk of Mortality among Patients with Acute Pancreatitis: Findings from A US National Hospital Registry
  1. N.K. Mazumder1,
  2. P. Trivedi1,
  3. M. Mujib2,
  4. B. Mehta2,
  5. N. Mujib3,
  6. W.S. Aronow2,
  7. P. Efthimiou4,5,
  8. T. Toronjadze1,
  9. K. Beekman1,
  10. J.H. Kim6
  1. 1Medicine, Flushing Hospital Medical Center, Flushing, NY
  2. 2Medicine, New York Medical College, Valhalla, NY
  3. 3Medicine, Cape Fear Valley Hospital, Fayetteville, NC
  4. 4Rheumatology, Lincoln Medical and Mental Health Center, Bronx, NY
  5. 5Medicine, Weill Cornell Medical Center, New York
  6. 6Gastroenterology, Flushing Hospital Medical Center, Flushing, NY, United States


Background Acute pancreatitis is a rare presentation among systemic lupus erythematosus (SLE) patients. However, the association of SLE and clinical outcomes among acute pancreatitis has not been studied.

Objectives To study the effect of SLE and in-hospital mortality among patients hospitalized with acute pancreatitis from a US national database.

Methods We used the 2002-2010 Nationwide Inpatient Sample (NIS) databases to evaluate patients who were hospitalized for acute pancreatitis (ICD 9 code 577.0). Discharge weights were used to enable nationwide estimates. Of a total of approximately 80 million hospitalizations in NIS databases, 2.3 million were hospitalized for acute pancreatitis, of which, 14,553 (0.6%) had SLE. Multivariable logistic regression models were used to assess the effect of SLE on in-hospital mortality among these patients.

Results Acute pancreatitis patients had a mean age of 53 (±18) years and 49% were women. Race distribution comprised of 50% Caucasians, 13% African-Americans and 10% Hispanics. In-hospital mortality occurred in 1.5% and 1.2% of patients with and without SLE respectively (unadjusted odds ratios, 1.26; 95% confidence intervals, 1.10-1.44; P=0.001). After controlling for patient risk factors, hospital characteristics, SLE patients independently conferred the higher adjusted odds of in-hospital mortality (adjusted odds ratios, 1.86; 95% confidence intervals, 1.62-2.14; P<0.001). Acute pancreatitis patients with SLE had a longer mean length of stay (mean stay, 7 vs 5 days, P<0.001) and a higher mean hospital charges ($33,984 vs. $27,126 P<0.001).

Conclusions In this nation-wide study, SLE was rare among acute pancreatitis hospitalizations and was independently associated with in-hospital mortality. SLE in acute pancreatitis was also associated with longer length of hospital stay and an increased hospital cost.

Disclosure of Interest : None declared

DOI 10.1136/annrheumdis-2014-eular.5410

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