Background Juvenile-onset systemic lupus erythematosus (JSLE) is an autoimmune disorder with multisystem involvement, leading to inflammatory damage to the joints, kidney, central nervous system, and hematopoietic system affecting children and adolescents. According to these multisystem deteriorations lead reduction in health-related quality of life (HRQL) in patients with JSLE.
Objectives The aim of this study was to assess the relationship between HRQL and pain in patients with JSLE.
Methods 19 patients (female=16, male=3) with JSLE and their parents were enrolled in the study. The subjects were recruited in a pediatric rheumatology clinic. They were diagnosed with JSLE by a pediatric rheumatologist based on the clinical diagnostic criteria. Patients with recent diagnoses of JSLE and those with mental deficits were excluded. Visual Analog Scale (VAS) was used to evaluate pain (during rest, activity and exercise) and well being. Functional ability was evaluated with Childhood Health Assessment Questionaire (CHAQ). Also, the Turkish version of PedsQL 3.0 Arthritis Module was used to evaluate HRQL.
Results The mean age was 14.16±2.66 years (range 12–18 years). The mean disease duration was 3.42±2.76 years (range 0.08–15 years). The mean of number of affected joint was 2.16±2.92. Significant relationships were found between score of VAS-pain (during activity) and number of affected joint (r=0.801 p=0,000) and score of PedsQL-patient's report (r=-0.655 p=0,002) and score of PedsQL-parent's report (r=-0.670 p=0,002) and score of VAS-well being (r=0.759 p=0,000).
Conclusions This study demonstrated that there is significant relationship between increased pain and reduction health-related quality of life in patients with JSLE. Due to number of affected joint increasing pain may results impairment daily functions and reduction health-related quality of life in patients with JSLE. Therefore, we concluded that reduction of pain has substantial role on improving of health-related quality of life in treatment of patients with JSLE.
Disclosure of Interest None declared
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