Background Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in human. There is a lack of comprehensive population data for effect of caffeine intake on urate metabolism.
Objectives The aim of this study was whether coffee, tea, and caffeine intake influences serum uric acid and the risk of hyperuricemia in the Korean Multi-Rural Communities Cohort.
Methods A total of 9400 subjects were enrolled in this study. Assessment of various dietary intakes such as coffee and tea was performed using food frequency questionnaire. The content of caffeine was calculated from coffee (74 mg/cup) and tea (15 mg/cup) intake over the past year. Multivariate logistic regression models, multiple linear regression models, and analysis of covariance were applied to identify association of dietary intakes with serum uric acid level or the risk of hyperuricemia.
Results No trends for coffee, tea, and caffeine intakes according to each quintile to serum uric acid were found in males, although there were weak marginally significant trends between content of coffee and caffeine intake and serum uric acid level in females (p=0.07 of both). Tea intake in males and caffeine intake in females were significantly different between non-hyperuricemia and hyperuricemia, (p=0.04 and p=0.04, respectively). Significant association of serum uric acid level with tea intake in males (b =0.0006, p=0.02) and with tea intake and caffeine intake in females (b =0.0003, p=0.04 and b =0.0006, p=0.02, respectively) were observed. There was no effect of coffee, tea, and caffeine intake on the risk of hyperuricemia in both males and females.
Conclusions This study suggests that caffeine consumption might have an effect on serum uric acid in females. However, coffee, tea, and caffeine intakes were not associated with the risk of hyperuricemia.
Acknowledgements This research was supported by a fund (2004-E71004-00, 2005-E71011-00, 2006-E71009-00, 2007-E71002-00, 2008-E71004-00, 2009-E71006-00) by Research of Korea Centers for Disease Control and Prevention.
Disclosure of Interest None declared