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AB0912 Effect of Corticosteroids on Bone Mineral Density and Body Composition in Patients with Juvenile Idiopathic Arthritis
  1. R. Lahlou,
  2. S. Rostom,
  3. A. Hari,
  4. N. Bensaoud,
  5. R. Bahiri,
  6. N. Hajjaj-Hassouni
  1. Rheumatology, Mohamed V Souissi University, Ayachi Hospital Ibn Sina Universitary Hospitals, Rabat-Salé, Rabat, Morocco


Objectives Evaluate the association between corticosteroid therapy, body composition and bone mineral density in patients with juvenile idiopathic arthritis.

Methods Our study was a cross-sectional study including Moroccan patients with juvenile idiopathic arthritis according to the International League of association of Rheumatology (ILAR) criteria, seen in rheumatology consultation or hospital. Sociodemographic and clinical data of the patients were collected. Bone mineral density of patients (BMD g/cm2) was measured by DXA X-ray Lunar Prodigy scanner. It was measured in two sites: the lumbar spine (L1, L4) and the whole body.

Lean and fat mass were measured by the same device at the whole body and expressed in grams.

Results 33 patients were included, the mean of their age was 10±4.35 years old, with a male predominance (54.5%), the median of disease evolution was 2 (1 - 4.5) years. Twenty for percent had a systemic JIA, 27% had an oligoarticular JIA and 48% had a polyarticular JIA. nineteen (57.6%) of our patients were receiving corticosteroid therapy, the median of daily intake dose was 10mg (0-15), the median of treatment duration was 3 years (1-6) and the median of cumulative dose was 10950mg (5475 -21 900). The median of BMD in the whole body, lumbar spine, lean mass and fat mass were respectively 0.720 g/cm2 (0700-0900) 0.620 g/cm2 (0530-0900), 20.49g (15.96-33.45), 4.97g (3.63-15.09).

There was no significant correlation between the daily dose of corticosteroids and lean body mass (p=0.23), fat mass (p=0.21), BMD of the lumbar spine, p=0.82 or BMD of whole body p=0.86. We didn't find a significant correlation between the cumulative dose of corticosteroids and lean body mass (p=0.079), fat mass (p=0.05), lumbar spine BMD (p=0.27) and the hole body BMD (p=0.36).

Conclusions This study suggests that taking steroids does not affect the BMD or body composition in children with JIA.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5806

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