Objectives To evaluate the status of lipid peroxidation (LPO) and antioxidant protection in children with juvenile scleroderma (JS) and juvenile idiopathic arthritis (JIA).
Methods Baseline demographics, clinical characteristics and disease activity parameters have been documented. Determination of parameters of LPO and the content of fat-soluble and water-soluble ability (ACL and ACW) of substances in blood serum have been carried out.
Results 34 children with juvenile scleroderma (JS) and 48 children with juvenile idiopathic arthritis (JIA) were examined. At investigation the median ages at JIA were 11.9±4.3 years and at JS were 12.3±3.6 years. The median age at JIA onset was 6.8 years (STD (standard deviation) 4.3, range 0.5-14.7). The median age at JS onset was 7.4 years (STD 3.9, range 1.4-13.8). The median disease duration was 5.1 years (STD 4.0). ANA positivity has been found in 52.4%. The most frequent included JIA categories were rheumatoid factor negative polyarticular JIA with 62.5% and oligoarticular JIA with 22.9%. 14.6% of patients had a history of systemic JIA.
Significant (P<0.05) increase in the level of intermediate and end products of LPO in the serum of patients in clinical groups compared with the control group were revealed in the study. Content of dienkonyugates in the blood of children with JS were 6.81±1.01, in children with JIA – 3.26±0.54, in healthy children – 1.65±0.4. Content of dienketones children with JS was 9.88±1.24, in children with JRA – 4.22±0.39, healthy children – 0.19±0.08. Content of malonic dialdehyde in children with JS was 17.9±2.7 mmol/l, in children with JIA – 9.14±1.84 mmol/l, in healthy children – 6.96±1.42 mmol/l. Significant (P<0.01) reduction ACW and ACL substances in the ability of blood serum of children both clinical groups compared with the control group were established. ACW content in children with JS was 6.88±1.24 mmol/l in children with JIA – 11.52±5.6 mmol/l in healthy children – 13.72±5.24 mmol/l, the content of ACL in children with JS – 5.16±1.03 mmol/l in children with JIA – 8.11±3.95 mmol/l in healthy children – 8.81±3.5 mmol/l.
Conclusions The findings suggest that activation of lipid peroxidation and violation processes of antioxidant protection in children with JIA and JS can help maintain a high intensity of immune inflammation in this pathology.
Disclosure of Interest None declared