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AB0893 Presence of Antibodies to Cyclic Citrullinated Peptides in Juvenile-Onset Systemic Lupus Erythematosu
  1. H. Zeng,
  2. H. Liu,
  3. Y. Liu,
  4. Q. Guan
  1. Guangzhou Women and Children's Hospital, Guangzhou, China

Abstract

Objectives To determine the prevalence of antibodies to cyclic citrullinated peptides (anti-CCP) in patients with juvenile-onset systemic lupus erythematosus (JSLE) and its potential clinical significance.

Methods Anti-CCP was measured in sera from patients with JSLE (n=47), juvenile idiopathic arthritis (JIA, n=54) and the sera from age-matched healthy children (n-40) using the third generation of anti-CCP ELISA commercial kit. The association of anti-CCP with other laboratory parameters and clinical features, especially arthritic symptoms in JSLE was also analyzed. T-test, Mann-Whitney U test, Chi-square and Fisher's exact test were used for statistical analysis.

Results Out of the 47 JSLE patients, 6 (13%) were anti-CCP positive,which was significantly higher than that of the healthy controls (13% vs 0, P<0.05), but not difierent from that of the JIA group (26%, P=0.098). RF was more prevalent in JSLE patients with anti-CCP than patients without (83% vs 15%, P<0.01), but there was no difference in other laboratory parameters and the clinical features including the occurrence of arthritis (67% vs 51%, P>0.05). As one of the initial symptoms, arthritis was ohserved in 25 of 47 JSLE patients and no one had developed deforming athropathy. There was no statistical difference in anti-CCP positivity between JSLE patients with and without articular involvement (16% vs 9%, P>0.05). Anti-CCP was not detected in any of the 3 patients with JSLE who had experienced ioint pain and limited activity during 3 years foIlow-up.

Conclusions Anti-CCP could be detected in patients with JSLE.It is noteworthy when differentiate from juvenile idiopathic arthritis, but the presence of anti-CCP does not relate with the occurrence of arthritis at presentation and persistence of arthritis in JSLE.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5615

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