Objectives To determine the prevalence of antibodies to cyclic citrullinated peptides (anti-CCP) in patients with juvenile-onset systemic lupus erythematosus (JSLE) and its potential clinical significance.
Methods Anti-CCP was measured in sera from patients with JSLE (n=47), juvenile idiopathic arthritis (JIA, n=54) and the sera from age-matched healthy children (n-40) using the third generation of anti-CCP ELISA commercial kit. The association of anti-CCP with other laboratory parameters and clinical features, especially arthritic symptoms in JSLE was also analyzed. T-test, Mann-Whitney U test, Chi-square and Fisher's exact test were used for statistical analysis.
Results Out of the 47 JSLE patients, 6 (13%) were anti-CCP positive,which was significantly higher than that of the healthy controls (13% vs 0, P<0.05), but not difierent from that of the JIA group (26%, P=0.098). RF was more prevalent in JSLE patients with anti-CCP than patients without (83% vs 15%, P<0.01), but there was no difference in other laboratory parameters and the clinical features including the occurrence of arthritis (67% vs 51%, P>0.05). As one of the initial symptoms, arthritis was ohserved in 25 of 47 JSLE patients and no one had developed deforming athropathy. There was no statistical difference in anti-CCP positivity between JSLE patients with and without articular involvement (16% vs 9%, P>0.05). Anti-CCP was not detected in any of the 3 patients with JSLE who had experienced ioint pain and limited activity during 3 years foIlow-up.
Conclusions Anti-CCP could be detected in patients with JSLE.It is noteworthy when differentiate from juvenile idiopathic arthritis, but the presence of anti-CCP does not relate with the occurrence of arthritis at presentation and persistence of arthritis in JSLE.
Disclosure of Interest None declared
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