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AB0881 Biologic Disease Modifying Anti-Rheumatic Drug Use in the Treatment of Juvenile Idiopathic Arthritis: Data from the Rheumatic Diseases Portuguese Register, Reuma.Pt
  1. A.F. Mourão1,2,
  2. M.J. Santos1,3,
  3. J.A. Melo Gomes4,
  4. F.M. Martins5,
  5. F. Ramos6,
  6. S. Fernandes7,
  7. M. Salgado8,
  8. M. Guedes9,
  9. S. Carvalho10,
  10. J.A. Costa11,
  11. C. Duarte12,
  12. I. Brito13,14,
  13. R. Figueira15,
  14. G. Figueiredo16,
  15. A.C. Furtado16,
  16. A. Lopes1,
  17. M. Oliveira17,
  18. A. Rodrigues1,
  19. G. Sequeira18,
  20. M. Sousa7,
  21. J.C. Branco19,20,
  22. J. Eurico Fonseca16,
  23. H. Canhão16
  1. 1Rheumatology Research Unit, Centro Académico de Lisboa, Instituto de Medicina Molecular
  2. 2Centre for chronic diseases, Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon
  3. 3Rheumatology, Hospital Garcia de Orta, Almada
  4. 4Pediatric Rheumatology, Portuguese Institute of Rheumatology
  5. 5Rheumatology, Portuguese Society of Rheumatology
  6. 6Pediatric Rheumatology, Hospital de Santa Maria, CHLN, EPE
  7. 7Rheumatology, Portuguese Institute of Rheumatology, Lisbon
  8. 8Pediatric Rheumatology, Centro Hospitalar de Coimbra - Hospital Pediátrico, Coimbra
  9. 9Pediatric, Unidade de Imunologia Clínica, Porto
  10. 10Pediatric, Centro Hospitalar do Médio-Ave, Famalicão
  11. 11Rheumatology, Unidade de Saúde do Alto Minho, Ponte de Lima
  12. 12Rheumatology, Centro Hospitalar de Coimbra, Coimbra
  13. 13Rheumatology, Hospital de São João
  14. 14Rheumatology, Faculdade de Medicina da Universidade do Porto, Porto
  15. 15Rheumatology, Hospital Dr. Nélio Mendonça, Centro Hospitalar do Funchal, EPE, Funchal
  16. 16Rheumatology, Hospital do Divino Espírito Santo, Ponta Delgada
  17. 17Rheumatology, centro Hospitalar da Cova da Beira, Covilhã
  18. 18Rheumatology, Centro Hospitalar de Faro, Faro
  19. 19Rheumatology, Hospital Egas Moniz, CHLO, EPE
  20. 20Centre for chronic diseases, Nova Medical School, Lisbon, Portugal

Abstract

Background The Portuguese Society of Rheumatology developed the Rheumatic Diseases Portuguese Register (Reuma.pt) encompassing also Juvenile Idiopathic Arthritis patients followed by rheumatologists and pediatricians.

Objectives 1. To obtain an overview of biological agents use in Portuguese children with JIA. 2. To assess the effectiveness and safety of biological therapy at 6 months and 1 year of treatment.

Methods We retrieved data from Reuma.pt, until December 2013. We collected baseline patient and disease characteristics of patients with JIA who started treatment with biological agents. Follow-up data were analyzed and are presented at 6 months and 1 year. Disease activity was assessed using the number of active joints, ESR and CHAQ.

Results 812 patients with JIA,227 received biological therapy.The mean age at disease onset of patients treated with biologic DMARDs was 6.9±4.7years and the mean age for starting biological therapy was 16.1±9.4years. The most common JIA categories were polyarticular RF negative (23.3%), polyarticular RF+(17.5%) and extended oligoarticular (16.0%).The median duration of the first biological agent was 5.76years. Most patients were treated with antiTNF as first line (90.3%):etanercept 69.2%,adalimumab 12.8%,infliximab 8.4%. Mean baseline active joint count was 5.1±5.8, decreasing to 1.2±2.4 and 1.0±3.1 after 6 months and 1 year of therapy. Mean ESR was 33.9±25.3 mm/1sth and 26.9±23.9 and 19.1±180 after 6 months and 1 year. CHAQ decreased from 0.8±0.7 to 0.4±0.5 and 0.4±0.5 at 6 months and 1 year. 14.1% switched once to other biological therapy (3.08% in the first 6 months,4.4% in the first year), 5.73% switched twice (0.88% in the first 6 months,1.76% in the first year) and 2 patients (0.88%) switched 3 times after the first year of treatment. 14 serious adverse events were reported leading to discontinuation of the treatment, 6 in the first 6 months and 8 in the first year of treatment. There were no reported deaths. The one-year treatment retention with biological agents was 91%.

Conclusions JIA patients treated with biologics and registered in Reuma.pt showed a good profile of effectiveness and safety at 1 year.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3142

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