Background Effective of pain relief is an important element of the treatment of rheumatic diseases. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular class of analgesics. To predict their effect, depending on the particular clinical situation is an actual problem.
Objectives To evaluate the dependence of the efficiency of ketoprofen lysine salt (KLS) on a number of clinical factors, as well as the determination of the relationship between the level of analgesia and the subjective evaluation of the effectiveness of this drug.
Methods There are data of open 2-week observational study KLS outpatients with muscular-skeletal disorders, which suffered from severe pain. The study group included 4609 patients, the most part with back pain and OA, 64.4% of women and 35.6% of male, age 50.2±12.8 years. Physicians could prescribe at their own discretion different forms of KLS (intramuscular (i.m.), per os, topical) or their combinations. Treatment efficacy was assessed by the dynamics of pain (100- mm VAS) and satisfaction of patients (scale of 1-5 points, where “1” - no effect, and “5” - great effect).
Results Intensity of pain decreased from 67.93±15.63 to 15.96±13.48 mm, the dynamics of pain was -52.2±18.5 mm VAS. Most patients (87.1%) reported “excellent” and “good” effect of KLS. There was a strong correlation between satisfaction with care and the dynamics of pain. Thus, the difference between the valuation of reducing pain “1” and “2” was 14.3 (2.9-25.7), p=0.014; “2” and “3” - 11.1 (6.7-15.5), p<0.001; “3” and “4” - 8.5 ( 6.9-9.9), p<0.001; “4” and “5” - 14.2 (13.3-15.3) mm VAS, p<0.001. The safety of KLS was good: significant side effects were found in 1.3%. Was evaluated treatment satisfaction upon factors such as sex, age>60 years old, diagnosis of OA, applying KLS i.m., prior NSAIDs, use of muscle relaxants, and the absence of side effects. Gender, age, and prior use of NSAIDs did not affect satisfaction. The diagnosis of OA was associated with a significant reduction effect (OR, 95% CI) - 0.702 (0.645-0.764); use of i.m. injection, taking muscle relaxants, and absence of complications with increasing effect: 1.12 (1.51-2.77), 1.1 (1.06-1.11) and 2.05 (1.51-2.77).
Conclusions KLS is effective and relatively safe agent for the treatment of musculoskeletal pain. The difference in subjective valuation of KLS efficacy (for example, between “good” and “excellent”), identifying patients, on average, was associated with reduced pain by 12.0 (7.9-16) mm VAS. Efficacy of KLS was lower in patients with OA. Initiation of treatment with i.m. KLS, the combination with muscle relaxants and absence of complications increases the effectiveness of treatment.
Disclosure of Interest None declared
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