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AB0851 Laboratory Abnormalities in Tuberculous Spondylodiscitis
  1. H. Sahli,
  2. I. Cherif,
  3. R. Tekaya,
  4. A. Bachali,
  5. I. Mahmoud,
  6. O. Saidane,
  7. L. Abdelmoula,
  8. R. Zouari
  1. Rheumatology, hopital charles nicole, Tunis, Tunisia

Abstract

Background Tuberculous spondylodiscitis still frequent in our country. Biologic aspects can help diagnosis in some cases.

Objectives Our objective is to describe laboratory features of tuberculous spondylodiscitis among monocentric experience.

Methods This is a retrospective study which included medical records of patients treated for tuberculosis spondylodiscitis during the ten past years [2002-2012]. Biologic data were recorded and analysed.

Results Fifty seven cases of 29 women and 28 men of tuberculous spondylitis were treated during the ten past years. The mean age was 56.6 years (range 20 to 86 years). A contact history of tuberculosis was reported by 2 patients. The predisposing conditions were present in the third of cases: diabetes mellitus (13 cases), hepatic cirrhosis (5 cases) and high-dose corticosteroid intake (2 cases). It was a progressive starting of disease in two thirds of cases with median duration from the onset of symptoms to the diagnosis about 5.4 months (0.7 range to 24 months). Fever was observed in 29% of cases. Night sweats were present in 40% of cases Anorexia and weight loss were present in 71.9% of cases. Stiffnes was noted in 70% of cases. Pulmonary tuberculosis was associated in 3 cases and cutaneous tuberculosis was noted in 1 case. Biological inflammatory tests were rised in 91% of cases with a mean erythrocyte sedimentation rate of 93mm (range 2 to 150) and an average value of c Reactive protein of 55mg/l (range 0,2 to 331). The blood count showed leukocytosis (15 cases), lymphocytosis (9 cases), leukopenia and anemia in one case each. Disturbance of liver function tests was noted in 5 cases: hepatic cholestasis (n=3), hepatic cytolisis (n=2). Hyerglycemia was noted in the 13 cases of diabetes mellitus. Identification of mycobacterium tuberculosis in sputum was positive in 1 case.

Conclusions Inflammatory blood tests were rised in major of cases and leukocytosis was frequent among patients with tuberculous spondylodiscitis in this study.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.2758

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