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AB0836 Serum Uric Acid Level and Severity of Arterial Hypertension in A Treatment-Naive Hypertensive Population in Sub-Saharan Africa
  1. M. Doualla,
  2. G. Ashuntantang,
  3. H. Luma,
  4. F. Kamdem
  1. General Hospital Douala, Douala, Cameroon

Abstract

Background There is a known association between elevated serum uric acid (SUA) and incident hypertension (HTN) especially in Black males but the data is scarce in Africa.

Objectives We aimed at evaluating the relationship between the severity of HTN and SUA in a population of newly diagnosed and untreated HTN

Methods A cross sectional study conducted in Douala from January to December 2012. Participants were newly diagnosed untreated hypertensives recruited during a community based screening in an urban area of Cameroon. Patients with a history of gout were excluded. HTN was diagnosed after three consecutive blood pressure readings on 3 separate occasions following the screening exercise. SUA assays were performed on fasting blood samples.

Results Of the 839 participants included, 412 (49%) were males. Mean age was 50 years (range 29-81); mean BMI was 26.8; Mean SUA was 60.47±16.53 mg/l, with 65.1±16.54 mg/l (29- 112) in males and 55.98±15.26 mg/l (26- 108) in females 267 (31.8%) participants had elevated SUA levels. Among the participants with elevated SUA, 51% were males, 12.7% had a family history of HTN, 5.7% were smokers, and 8.2% had a fasting plasma glucose level ≥1.26g/L. 202 (75.6%) patients had stage 2 HTN and SUA levels were significantly higher compared to the other stages of HTN (p=0.001

Conclusions Stage 2 hypertension was strongly associated with elevated SUA levels in newly diagnosed and untreated hypertensives of indigenous black Africans. More studies are required to characterize this association.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5596

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