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AB0807 The Features of Bone Metabolism in Patients with Periodontal Diseases
  1. I. Mazur,
  2. V. Gabal
  1. Institute of Stomatology Department of Stomatology, Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine

Abstract

Background The aim of this study is to investigate the relationship between bone metabolic disturbances and periodontal diseases

Objectives Several studies discuss the relationship between systemic bone mineral density (BMD) and periodontal diseases. Osteoporosis or low systemic BMD should be considered as the risk factor for periodontal disease progression.

The purpose of this study was to determine the impact of bone metabolism on the periodontal status in the patients.

Methods The study included 89 patients (38 men and 51 women, mean age – 43.5±5.1 years) with the healthy periodontal status (HPS) and 231 patients (108 men and 123 women, mean age – 45.6±5.2 years) with generalized periodontitis (GP). Clinical conditions of periodontal tissue and radiographic determinations (panoramic X-Ray) were evaluated. Skeletal systemic BMD was measured by DXA. Metabolic processes of bone tissue were evaluated by bone turnover markers: bone tissue formation – osteocalcin (OC), bone-specific alkaline phosphatase (BAP) in serum and bone tissue resorption marker – deoxypiridinoline (DPD) in urine.

Results Comparative analysis of structural and functional state of bone tissue in patients showed a mineral density reduction in GP group compared to HPS, but these changes were not statistically significant. Disorders of bone tissue metabolism and dissociation in the processes of bone tissue remodeling were determined in patients with GP. The OC level in the patients with GP (18.89±0.87 ng/ml in men and 20.39±1.14 ng/ml in women) was statistically significantly (p<0.01) lower compared to the HPS group (24.14±1.04 ng/ml in men and 27.56±1.12 ng/ml in women). BAP show significant differences between groups.

The level of DPD in the GP group (5.78±0.79 mmol in men, 8.34±0.56 mmol in women) was significantly higher (p<0.01) compared to HPS group (3.57±1.12 mmol in men, 4.47±0.76 mmol in women).

Conclusions These results suggest that periodontitis associations with bone metabolic disturbances. In patients with periodontitis unbalanced bone remodeling was found: decreased bone formation and increased resorption

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5943

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