Background Osteoporosis and osteoarthritis are the common diseases in women in postmenopausal period. The reason why osteoarthritis and osteoporosis do not affect all women during their postmenopausal period has not been ascertained yet, the mechanisms of bone loss and cartilage degeneration when ageing have not been studied completely. Some literature data confirmed that indices of X-ray absorptiometry in women with hip osteoarthritis (HOA) are higher, but other did not confirm this point.
Objectives The aim was to study the particularity of relationship between state of bone and development of HOA in postmenopausal women.
Methods 69 women in postmenopausal period aged 50-79 years old with hip osteoarthritis were examined (mean age - 65.6±0.6 years old, weight - 74.1±0.8 kg, height – 158.6±0.4 cm, age of menopause - 49.2±0.4 years, duration of postmenopausal period - 16.2±0.6 years). The control group consisted the 60 healthy women without HOA. A diagnosis of osteoarthritis was performed due to the ACR criteria's. Women with primary knee osteoarthritis were excluded from the study. Bone state was measured by Dual-energy X-ray absorptiometry “Prodigy”(DXA) and calcaneus's quantitative ultrasound (QUS) densitometry “Sahara”.
Results We found the significant correlation between indices of DXA and ultrasound densitometry and presence and stage of HOA in postmenopausal women. In patients with HOA data of X-ray absorptiometry were significantly higher compared with healthy women (bone mineral density (BMD) of Trunk: F=7.71, p=0.006; Spine: F=6.32, p=0.01; Neck: F=4.08, p=0.04; Wards area: F=4.69, p=0.03 and Total BMD: F=5.61, p=0.02). Indices of ultrasound densitometry in women with HOA also were significantly higher compared with healthy women (Est BMD: F=6.49, p=0.01; BUA: F=9.8, p=0.002; SOS: F=3.45, p=0.05). In postmenopausal women we did not found significant relationship between some indices of DXA (L1-L4, total hip and radius) and presence of hip osteoarthritis.
Conclusions Presence and stage of HOA had significantly influence on ultrasound densitometry and DXA indices. It is important in assessment of bone state in women in postmenopausal period with hip osteoarthritis.
Disclosure of Interest None declared
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