Objectives to detect the association of serum uric acid level with carotid intima-media thickness (CIMT) in psoriatic arthritis (PsA) patients without clinical evidence of cardiovascular disease (CVD) and the possible value of serum uric acid as an indicator for atherosclerosis in PsA patients.
Methods thirty PsA patients (group I) and twenty age and sex matched control (group II) were included in this study. All were subjected to; clinical examination, measurements of blood pressure & body mass index and serum uric acid. Carotid B-mode ultrasonography was used for measurements of CIMT and the presence of plaques.
Results There was highly significant increase in the thickness of CIMT in the PsA patients with HU more than those without HU where means of CIMT in right side were1.01±0.29and 0.67±0.18 and in left side were 0.89±0.34 and 0.61±0.14 in both subgroups respectively (P<0.001), also there was highly significant increase in the frequency of plaques occurrence between both subgroups (P<0.001). A highly significant correlation was detected between CIMT and serum uric acid level in PsA patients (r=0.59, P<0.001). Serum uric acid had the highest CVD prediction validity at CIMT >0.9 mm as we found that the best cut-off value was at 7.3 mg/dl with estimated 85% Sensitivity and 65% specificity
Conclusions Serum uric acid is an independent risk factor aggravating subclinical atherosclerosis found in PsA patients. Uric acid could be a new potential marker for prediction of microvascular endothelial dysfunction in PsA patients.
Ramonda R, Lo Nigro A, Modesti V, Nalotto L, Musacchio E, Iaccarino L, et al. Atherosclerosis in psoriatic arthritis. Autoimmunity Reviews 2011;10:773-778.
Disclosure of Interest None declared
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