Objectives To evaluate the clinical features and course of ankylosing spondylitis (AS) in women according to the City rheumatological center in Kazan.

Methods The study involved two groups of patients with AS: 23 women and 25 men, respectively, matched by age (average - 33,1±9,6 years), established diagnosis (average - 3,4±1,6 years). The presence of inflammatory back pain (IBP), BASDAI, ASDAS, BASFI indexes, presence of HLA B27, the results of X-ray of the sacroiliac joint were evaluated.

Results In women, the disease duration from first symptoms to diagnosis was 4,6±1,8 years, age at onset 26,3±4,9 years, in men these figures were 5,7±2,1 years and 25.6±3,8 years respectively. According to a survey of patients, disease onset in women was characterized by the presence of IBP (at 69.6%), occurring periodically (38.5%), peripheral arthritis clinic (60.9%), enthesitis (21, 7%), uveitis (4.3%). Among men IBP occurred in 60%, less recurring (14%), arthritis occurred in 40%, enthesitis - 75%, uveitis - 8%. At the time of examination in women peripheral arthritis was significantly (at 69.6%, p<0.01) more common than in men (30.4%). Disease activity (BASDAI, ASDAS) were comparable in two groups. Functional impairment was higher in men (BASFI=5,6±1,2) than in women group (BASFI=4,5±1,0). According to the results of X-ray stage 0-1 sacroiliitis detected in 17.4% of women and 12% of men, the second stage - in 47.8% of women and 44% of men, the third stage - in 34.8% and 36% respectively, the fourth stage - 8% of men.

Conclusions AS in women has several significant features: IBP at onset of the disease is less common and is less permanent, more often peripheral joints are involved, enthesitis and uveitis are rarely diagnosed. AS in women is characterized by slower radiological progression.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3759