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AB0718 Relationship between Disease Activity and Cardiovascular Comorbidities in Ankylosing Spondylitis
  1. R. Balabanova,
  2. M. Podryadnova,
  3. M. Urumova,
  4. S. Erdes
  1. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Background In ankylosing spondylitis hart and vascular involvement mainly due to systemic process.

Objectives To assess prevalence and specification of cardiovascular comorbidities, its relationship with disease activity in AS patients.

Methods We studied 200 AS pts (m:f 146:54): mean age 34,9±9,5, disease duration 49 [5-396] month, mean age of disease onset 30,1±9,7, 72% were with axial involvement. ECG, echocardiography, metabolic syndrome characteristics were accessed.

Results Mean body mass index was 25±4,4, including 53% pts wit overweight. 78 (39%) from the 200 pts performed dislipidemiya: higher cholesterol level (18%), LDL (38%), decrease of HDL (2%). Pathological changes on the ECG were detected in 40% cases: hypertrophy of the left ventricular myocardium (11, 2%), incomplete bundle-branch block (11,2%), and atrioventricular block (5%). Echocardiography present in 24 pts. Pericarditis with a small effusion detected in 17% pts, 46% pts had induration/dilatation of aorta, valve apparatus deficiency mostly 1 stage -mitral (63%), tricuspid (50%), pulmonary (21%), aortic (8%). Arterial hypertension (AH) were performed in 48 pts (24%), mean age 44,0±7,7, other 52 pts have no AH (middle age 33,0±6,6 years). In AH pts 75% were with high level of BASDAI (>4) (p=0,0017).

Conclusions Pathological changes on the ECG and Echocardiography have no significant clinical manifestations. AH developed significantly more frequently in AS patients with high disease activity.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3643

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