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AB0691 Association between MRI Inflammation and Disease Activity in Early Axial Spondyloarthritis
  1. E. Gubar,
  2. A. Smirnov,
  3. E. Tukhova,
  4. T. Dubinina,
  5. A. Demina,
  6. A. Godzenko,
  7. O. Rumyantseva,
  8. S. Shubin,
  9. S. Gluhova,
  10. S. Erdes
  1. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Background The relationship between MRI inflammation and disease activity in early axial spondyloarthritis has not been proved sufficiently.

Objectives Establishing the association between clinical activity and MRI inflammation of sacroiliac joints (SIJs), lumbar spine (LS) and hip joints (HJs) in early axial spondyloarthritis (axSpA) patients (pts).

Methods 73 pts (33 men and 40 women) with early axSpa were examined: disease duration – 19.9±14.4 months. Pts fulfilled ASAS criteria. Age – 28.3±6.4 years, BASDAI – 4.1±1.9; ASDAS-CRP – 2.7±1.3; ESR – 21.9±17.6; CRP – 29.0±38.5; 66 (90.4%) pts were HLA-B27 positive. High disease activity was assumed in cases where BASDAI ≥4, ASDAS-CRP ≥2.1. MRI of SIJs, LS and hip joints (in case of hip joint involvement) was performed on Signa Ovation 0,35 T scanner (matrix 288x192).

Results MRI inflammation of SIJs and/or LS and/or HJs has been found in 62 (84.9%) pts: SIJs – in 53 (72.6%) pts, HJs – in 21 (28.7%) pts and LS, – in 8 (11.0%) pts. 42 out of 62 (67.7%) pts that had MRI inflammation in at least one of the three studied sections, had high ASDAS-CRP activity; and out of the group of patients without MRI inflammation (n=11) high ASDAS-CRP has been detected in 4 (36.4%) pts (p=0.047). High ASDAS-CRP activity was observed in 38 out of 53 (71.7%) pts that had active sacroiliitis (SI); out of the group of pts without MRI SI (n=20), high ASDAS-CRP was observed in 8 (40.0%) pts (p=0.012). No association has been found between MRI data and disease activity according to BASDAI.

Conclusions Correlation has been detected between inflammatory lesion in SIJs and/or LS and/or HJs and high disease activity according to ASDAS-CRP. There is an association between existence of active MRI SI and high ASDAS-CRP activity.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.4134

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