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AB0680 Baseline Characteristic of Newly Diagnosed Patients with Axial Spondyloarthritis: First Results from the Russian Cohort
  1. A.G. Bochkova,
  2. E. Gubar,
  3. O. Rumyantceva,
  4. T. Dubinina,
  5. S. Schubin,
  6. E. Tukchova,
  7. A. Smirnov,
  8. S. Erdes,
  9. E. Nasonov
  1. V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Background Application of the new ASAS classification criteria for axial SpA has allowed defining a broader spectrum of SpA patients, ranging from non-radiographic axial SpA (nr-axSpA) to classic ankylosing spondylitis (AS) according to modified New York criteria.

Objectives The present study describes the baseline characteristics of axial SpA patients presented for the first time in our department.

Methods The Moscow Institute of Rheumatology in 2012 year began to collect new cohort of patients with axial and peripheral SpA, according to the ASAS criteria (duration of back pain less than 5 years): at present 80 patients have been included.

Results Baseline characteristics of 73 newly diagnosed patients with axial SpA are reported (33 men, 40 women). Symptom duration varied from 3 month to 5 years (median: 19.9 month. Mean age was 28.3 years. All patients suffered from chronic back pain which started before 45 years; inflammatory back pain, defined by ASAS criteria was present in 80%. 90.4% of the patients were HLA-B27 positive and active inflammatory lesions on MRI were found in 85% patients: 72.6% - in sacro-iliac joints (SIJ), 11% - in lumbar spine, 28,7% - in the hip. Forty eight percent of the patients showed definite radiographic sacroiliitis according to modified New York criteria at first presentation. Symptom duration was comparable between the nr-axSpA and the AS groups. The female/male rate was reliably higher in nr-axSpA (24/13) versus AS (12/24), p=0.017. High CRP was reliably more frequently in AS patients. p=0.019. HLA-B27 positive and inflammatory parameters were equally present in both groups. Extra-articular manifestations were higher in the nr-axSpA group.

Conclusions We found high frequency of AS in newly diagnosed patients with early's axial SpA (48%) with comparable symptom duration. The nr-axSpA was observed more frequent in the women. The prevalence of extra-articular manifestations was low and they were only indicated in patients with nr-axSpA.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.2384

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