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AB0676 Neutrophil Lymphocyte Ratio Can be a Valuable Marker in Defining Disease Activity in Patients with As
  1. Y. Pehlivan,
  2. B.N. ÇOskun,
  3. M.F. Öksüz,
  4. E. Dalkılıç,
  5. A.N. Tufan
  1. Rheumatholy, Uludag University School of Medicene, Bursa, Turkey

Abstract

Background Erythrocyte sedimentation rate (ESR) and serum C reactive protein (CRP) are two common tools for indicating systemic inflammatory disease such as ankylosing spondylitis (AS). Recently, neutrophil lymphocyte ratio (NLR) has emerged as an easy and reliable method for this purpose in several inflammatory disease. In this study we aimed to evaluate the role of NLR for indicating inflammation and also to compare its relation with other measures such as ESR, CRP and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).

Objectives In this study we aimed to evaluate the role of NLR for indicating inflammation and also to compare its relation with other measures such as ESR, CRP and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).

Methods A total of 35 patients who had a full dose of non-steroid anti-inflammatory drugs (NSAIDs) at least three months and a BASDAI score above 4 or active sacroileitis and a total of 38 healthy volunteers were included in the study. The patients' charts were investigated retrospectively. The patient group was enrolled for treatment with one of anti-Tumor Necrosis Factor (TNF) drugs. Total blood count, ESR, CRP, BASDAI score were obtained before and three months following the treatment. NLR was found with a mathematical calculation of ratio of neutrophils with lymphocytes.

Results The mean NLR value of the control group and patients was 1.90±0.89 and 2.67±1.17 respectively (p<0.05). After a 3 months course of treatment the patient group had a mean NLR value of 1.8±0.7 which was significantly lower than pretreatment values (p<0.001). The post treatment mean ESR, CRP and BASDAI scores were significantly lower than mean baseline scores (p<0.001, p: 0.007, p ..., respectively). Also, NLR was found to be correlated with BASDAI, ESR and CRP (r=0.388, p<0.001; r=0.455, p<0.0001 and r=0.3389, p<0.005 respectively).

Conclusions NLR could be reliable and easily accessible method for follow up of patients with AS

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Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.4303

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