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AB0640 Bone Mineral Density in Patients with Systemic Sclerosis
  1. R. Alekperov,
  2. A. Smirnov,
  3. N. Toroptsova,
  4. E. Cheremukhina
  1. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Background Studies of bone mineral density (BMD) in patients with systemic sclerosis (SSc) showed its decreasing in comparison with healthy control. Prevalence of low bone mass and severity of BMD decreasing differ significantly between patients from different countries and vary from 17% in China (Mok CC, et al. 2012) to 77% in Spain (Rios-Fernández R, et al, 2012).

Objectives To assess BMD and frequency of osteoporosis (OP) in patients with SSc in Russia.

Methods In case-control study BMD was evaluated in 52 postmenopausal women with SSc (16 – diffuse and 36 – limited form), mean age 57,6±7,1yrs and mean disease duration 11±8 yrs. Forty four healthy postmenopausal women (mean age 59,2±6,6yrs) served as control. BMD was measured at the lumbar spine (LS), femoral neck (FN) and total hip (TH) by DXA (Hologic 4500A). BMD decreasing grade was determined in according to WHO criteria

Results BMD was significantly decreased in SSc women in comparison with control group: in LS – 0,804±0,090 vs 0,861±0,092 g/sm2 (p=0,025); in FN – 0,670±0,128 vs 0,736±0,112 g/sm2 (p=0,037), and in TH – 0,801±0,160 vs 0,884±0,124 g/sm2 (p=0,03). Frequency of OP in SSc group was significantly more often than in control group (59% vs 11%, p<0,0001).

BMD didn't differ between pts with diffuse or limited SSc. Decreasing of BMD in LS, FN and TH associated with age (r=-0,40, p<0,001; r=-0,48, p<0,001; r=-0,38, p=0,002, respectively), duration of postmenopausal period (r=-0,44, p<0,001; r=-0,42, p<0,001; r=-0,33, p=0,016, respectively), duration of SSc (r=-0,21, p=0,033; r=–0,37, p=0,001; r=-0,36, p=0,004, respectively) and hsCRP level (r=-0,22, p=0,041; r=-0,26, p=0,045; r=-0,35, p=0,011). BMD of FN and TH correlated also with daily dose of glucocorticoids (GC) (r=-0,34, p=0,025; r=-0,37, p=0,023, respectively). T-score was significantly lower in pts treated with GC than in GC free pts in LS (-2,01±1,52 vs -1,17±1,42, p=0,012), FN (-2,38±1,18 vs -1,26±1,25, p=0,003) and TH (-1,98±1,34 vs -0,84±1,19, p=0,011)

Conclusions OP occurs in more than half cases of SSc pts. Low BMD in SSc pts apart from traditional risk factors of OP is associated with disease duration and inflammatory activity.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5426

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