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AB0639 The Prevalence of Cardiac Arrhythmias and Conduction Defects in Patients with Systemic Sclerosis
  1. R. Alekperov1,
  2. E. Cheremukhina2,3,
  3. R. Alekperov2,
  4. D. Novikova2,
  5. L. Ananyeva1,2
  1. 1Nasonova Research Institute of Rheumatology, Moscow
  2. 2Institute of Rheumatology
  3. 3Moscow Institute of Rheumatology, Moscow, Russian Federation


Objectives To study a frequency of cardiac arrhythmias and conduction disturbances by standard ECG and 24-hour Holter monitoring (HM)

Methods Eighty pts with systemic sclerosis (SSc) (28 – diffuse, and 52 – limited form), age 21-80y (52±11), and disease duration of 1-36y (9,8±8,6). All pts underwent standard ECG and 24-hour HM

Results By standard ECG cardiac arrhythmias were found in 14 patients (17%), including premature supraventricular beats (PSVB) in 10 (13%) patients and premature ventricular beats (PVB) in 7 (9%) of them. Conduction disorders were seen in 28 (35%) patients, including right bundle branch block in 7 (9%) patients, left bundle branch block in 16 (20%), and combined right and left bundles branch block in 5 (6%) from 80 pts.

By HM, PSVB were found in 74 (93%) patients, and PVB in 52 (65%). Twenty nine (36%) patients showed grade III, IVA, IVB or V of ventricular arrhythmias, according to Lown's classification. There also were atrioventricular block of 1st grade in 1 case, and 2nd grade – in 2 patients.

Twenty one patients had coronary artery disease (CAD) and there weren't any differences of arrhythmias' frequency between patients with or without CAD.

Arrhythmias in group of patients under 50 year and in group of older patients were found in 10 from 28 (35%) patient and in 34 from 52 (65%) patients, respectively (p=0,001). There weren't any associations of the frequency of arrhythmias with duration of disease and clinical forms of SSc. The frequency of cardiac arrhythmias didn't differ between patients group with disease duration lesser 5 years and in patients with disease duration greater than 5 years.

Conclusions Cardiac arrhythmias and conduction abnormalities are common in patients with SSc and are revealed significantly often by HM in comparison with standard ECG

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5182

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