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AB0618 Comparison of Selected Serological and Clinical Parameters in Female and Male Patients with Systemic Sclerosis
  1. E. Wielosz,
  2. M. Majdan,
  3. D. Suszek,
  4. M. Dryglewska
  1. Department of Rheumatology, Medical University of Lublin, Lublin, Poland

Abstract

Background The course of systemic sclerosis (SSc) can differ in female and male patients. It has been suggested earlier that in male patients, the incidence rates of diffuse cutaneous SSc, scleroderma renal crisis and digital ulceration are higher.

Objectives The aim of the study was to compare the selected serological and clinical parameters in male and female patients with SSc.

Methods The study encompassed 101 patients with SSc, including 23 men, hospitalised in the Department of Rheumatology and Connective Tissue Diseases in the years 2006-2012 (Table 1). The study groups of men and women were assessed according to the SSc subtype, presence of antinuclear antibodies considered SSc markers and incidence of internal organ involvement

Results There were no statistically significant differences in the incidence of a-Scl-70 and anti-centromere antibodies observed in the groups of female and male patients. The incidence of scleroderma renal crisis was significantly higher in the male group (3/23 vs. 2/78 p=0.04). On the other hand, the incidence of calcifications was significantly lower in the male group compared to the female group (1/23 vs. 20/78 p=0.02). Diffuse cutaneous SSc was observed more commonly in men than in women (13/23 vs. 25/78 p=0.03). The time from development of Raynaud's phenomenon to the diagnosis was significantly shorter in male patients compared to female patients (3.2±4.7 vs. 7.5±7.1).

Conclusions The serological profiles of female and male patients with SSc are comparable. The incidence of diffuse cutaneous SSc is higher in men compared to women. The time from development of Raynaud's phenomenon to the diagnosis is shorter in the male group than in the female group. The incidence of scleroderma renal crisis is higher, whereas of calcifications - is lower in SSc men compared to SSc women.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.1286

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