Cold hands may be the clinical presentation of Raynaud phenomenon (RP). RP may represents a benign condition (primary RP) often observed in healthy subjects, especially women, due to an exaggerated response to the physiological cold-induced vasospasm. However, it may be associated (secondary RP) with several clinical conditions, including connective tissue diseases. In particular, systemic sclerosis (SSc) has RP as its first clinical manifestation (1-2). Nailfold videocapillaroscopy (NVC) is a safe and reliable method to study peripheral microcirculation and its early morphological changes, especially during the transition from primary to secondary RP, as well as antinuclear antibodies are one of the laboratory examinations of choice to investigate this clinical condition (3-5). EULAR/ACR criteria are recently been proposed to classify SSc (6). A correct early diagnosis of the RP is the basis of effective treatment and follow-up of these patients, in order to predict and prevent major clinical complications (1,2,5,6).
The clinical case of a woman complaining of cold hands and, two years later, sclerodactily will be presented and discussed.
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Disclosure of Interest None declared