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Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK
  1. B de Klerk,
  2. F P J G Lafeber,
  3. W E van Spil
  1. Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
  1. Correspondence to B de Klerk, Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; bo.deklerk{at}gmail.com

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The urinary level of the carboxy-terminal telopeptide of collagen type II (uCTX-II) currently is one of the most frequently used biochemical markers for assessing collagenolysis in articular cartilage during osteoarthritis. However, we published data suggesting release of CTX-II epitope from bone in Cohort Hip and Cohort Knee (CHECK), a large cohort of subjects with very early stage knee and/or hip osteoarthritis. As was observed for markers of bone metabolism, uCTX-II showed an abrupt increase in women aged 48–53 years that appeared to be attributable to menopause.1 Moreover, earlier work had already shown that uCTX-II has specifically strong associations with marker of bone metabolism as compared …

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