Article Text

PDF
Correspondence
Comment on: ‘Spondyloarthritis: may the force be with you?’, the Editorial by McGonagle et al
  1. Leonie van Duivenvoorde,
  2. Dominique Baeten
  1. Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands
  1. Correspondence to Dr Leonie van Duivenvoorde, Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Meibergdreef 9, Room K0-105, Amsterdam 1105AZ, The Netherlands; l.m.vanduivenvoorde{at}amc.uva.nl

Statistics from Altmetric.com

We read with great interest the editorial by McGonagle et al1 on the recent study by Jacques et al.2 Jacques et al describe a series of elegant experiments in TNFΔARE mice demonstrating that mechanical unloading by tail suspension alleviates peripheral arthritis and explore the molecular mechanisms underlying this phenomenon.

McGonagle et al begin their editorial by stating that Jacques et al demonstrated that experimental spondyloarthritis (SpA) might be a biomechanically triggered process. This conclusion is surprising as Jacques et al did not perform any experiments supporting this suggestion. On the contrary, their experiments used the opposite approach and indicated that mechanical unloading alleviates tumour necrosis factor (TNF)-induced arthritis. This is emphasised …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.