Statistics from Altmetric.com
Midline destructive lesion (MDL), also known as ‘lethal midline granuloma’, represents a fibroinflammatory condition characterised by relentless erosion of the nose, paranasal sinuses and palate.1 ,2 Disease attribution remains elusive for many cases, which continue to be labelled ‘idiopathic’.2
Four patients, two males and two females, were referred because of progressive erosion of midline facial structures that had occurred over 2–3 years. Their median age was 40 years (range 27–54). Presenting symptoms included chronic sore throat, difficulty swallowing (nasal regurgitation) and progressive nasalisation of speech. Tissue destruction developed insidiously in all four patients, initially as small ulcerative lesions of the soft palate and nasal septum that enlarged gradually into perforations of palatal and nasal structures. Spontaneous loss of the uvula occurred in three patients. Three had palatal prostheses assembled in order to prevent the passage of food into the nasopharynx (figure 1A,B). All four developed saddlenose deformities.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.