Low-dose aspirin use and recurrent gout attacks
- 1Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
- 2The Data Coordinating Center, Boston University School of Public Health, Boston, Massachusetts, USA
- 3Department of Rheumatology, University of Sydney, St Leonards, New South Wales, Australia
- Correspondence to Dr Yuqing Zhang, Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University School of Medicine, 650 Albany St., Boston, MA 02118, USA;
- Received 29 August 2012
- Revised 12 December 2012
- Accepted 29 December 2012
- Published Online First 23 January 2013
Objective To examine the association between cardioprotective use of low-dose aspirin and the risk of recurrent gout attacks among gout patients.
Methods We conducted an online case-crossover study of individuals with gout over 1 year. The following information was obtained during gout attacks: the onset dates, symptoms and signs, medications, and exposure to potential risk factors, including daily aspirin use and dosage, during the 2-day hazard period prior to the gout attacks. The same exposure information was also obtained over 2-day control periods.
Results Of the 724 participants analysed, 40.5% took aspirin ≤325 mg/day during either a hazard or a control period. Compared with no aspirin use, the adjusted OR of gout attacks increased by 81% (OR=1.81, 95% CI 1.30 to 2.51) for ≤325 mg/day of aspirin use on two consecutive days. The corresponding ORs were stronger with lower doses (eg, OR=1.91 for ≤100 mg, 95% CI 1.32 to 2.85). These associations persisted across subgroups by sex, age, body mass index categories and renal insufficiency status. Concomitant use of allopurinol nullified the detrimental effect of aspirin.
Conclusions Our findings suggest that the use of low-dose aspirin on two consecutive days is associated with an increased risk of recurrent gout attacks. Recommended serum urate monitoring with concomitant use and dose adjustment of a urate-lowering therapy among patients with gout may be especially important to help avoid the risk of gout attacks associated with low-dose aspirin.