Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

Iain B McInnes; Joachim Sieper; Jürgen Braun; Paul Emery; Désirée van der Heijde; John D Isaacs; Georg Dahmen; Jürgen Wollenhaupt; Hendrik Schulze-Koops; Joseph Kogan; Shenglin Ma; Martin M Schumacher; Arthur P Bertolino; Wolfgang Hueber; Paul P Tak

doi:10.1136/annrheumdis-2012-202646

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Clinical and epidemiological research

Extended report

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

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	Abstract	Full	Pdf
Jan 2013	417	16	88
Feb 2013	539	169	192
Mar 2013	215	84	71
Apr 2013	273	78	104
May 2013	163	51	57
Jun 2013	200	64	67
Jul 2013	234	60	65
Aug 2013	131	56	67
Sep 2013	142	58	66
Oct 2013	188	59	75
Nov 2013	128	38	51
Dec 2013	356	44	76
Jan 2014	2333	95	284
Feb 2014	818	76	131
Mar 2014	492	82	95
Apr 2014	369	93	103
May 2014	240	90	76
Jun 2014	259	71	90
Jul 2014	235	43	71
Aug 2014	164	51	53
Sep 2014	224	53	83
Oct 2014	222	75	88
Nov 2014	164	67	72
Dec 2014	139	43	63
Jan 2015	205	57	65
Feb 2015	162	52	68
Mar 2015	222	61	83
Apr 2015	195	61	80
May 2015	172	56	71
Jun 2015	180	66	74
Jul 2015	168	57	64
Aug 2015	147	52	54
Sep 2015	198	50	55
Oct 2015	130	28	48
Nov 2015	155	46	49
Dec 2015	191	40	52
Jan 2016	175	57	67
Feb 2016	132	45	56
Mar 2016	185	37	50
Apr 2016	213	57	63
May 2016	147	20	48
Jun 2016	164	37	32
Jul 2016	89	37	33
Aug 2016	110	16	24
Sep 2016	135	42	31
Oct 2016	168	23	29
Nov 2016	162	26	42
Dec 2016	125	38	33
Jan 2017	167	37	42
Feb 2017	210	39	59
Mar 2017	142	31	36
Apr 2017	153	53	26
May 2017	163	58	62
Jun 2017	148	37	53
Jul 2017	305	37	57
Aug 2017	346	28	52
Sep 2017	310	27	35
Oct 2017	376	42	60
Nov 2017	413	49	43
Dec 2017	424	29	26
Jan 2018	373	24	38
Feb 2018	285	34	29
Mar 2018	338	45	24
Apr 2018	282	21	8
May 2018	404	20	12
Jun 2018	223	21	13
Jul 2018	249	31	19
Aug 2018	146	17	14
Sep 2018	190	18	15
Oct 2018	289	36	31
Nov 2018	267	25	20
Dec 2018	244	28	19
Jan 2019	335	28	17
Feb 2019	169	20	16
Mar 2019	187	23	19
Apr 2019	172	24	17
May 2019	182	18	16
Jun 2019	136	17	12
Jul 2019	114	30	19
Aug 2019	247	8	6
Sep 2019	178	5	4
Oct 2019	267	18	11
Nov 2019	208	24	12
Dec 2019	175	15	10
Jan 2020	136	14	8
Feb 2020	132	20	13
Mar 2020	108	18	12
Apr 2020	151	16	14
May 2020	138	14	15
Jun 2020	112	13	8
Jul 2020	105	7	11
Aug 2020	82	10	12
Sep 2020	123	6	6
Oct 2020	106	20	15
Nov 2020	134	13	7
Dec 2020	103	6	1
Jan 2021	103	6	2
Feb 2021	147	16	16
Mar 2021	114	14	6
Apr 2021	104	13	6
May 2021	48	8	10
Jun 2021	8	7	5
Jul 2021	20	16	18
Aug 2021	12	12	3
Sep 2021	22	19	6
Oct 2021	69	10	3
Nov 2021	118	8	2
Dec 2021	83	11	1
Jan 2022	118	15	8
Feb 2022	104	6	6
Mar 2022	217	15	11
Apr 2022	136	3	5
May 2022	217	14	13
Jun 2022	125	14	4
Jul 2022	170	15	10
Aug 2022	225	16	4
Sep 2022	136	16	4
Oct 2022	124	8	7
Nov 2022	169	8	2
Dec 2022	133	5	1
Jan 2023	322	22	7
Feb 2023	142	9	4
Mar 2023	177	23	14
Apr 2023	91	8	4
May 2023	171	16	14
Jun 2023	109	6	2
Jul 2023	109	9	2
Aug 2023	102	8	2
Sep 2023	103	20	4
Oct 2023	194	16	7
Nov 2023	233	25	10
Dec 2023	191	28	3
Jan 2024	193	20	24
Feb 2024	244	23	7
Mar 2024	116	16	6
Total	28041	4375	4796

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