A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

Evangelos Evangelou; Hanneke J Kerkhof; Unnur Styrkarsdottir; Evangelia E Ntzani; Steffan D Bos; Tonu Esko; Daniel S Evans; Sarah Metrustry; Kalliope Panoutsopoulou; Yolande F M Ramos; Gudmar Thorleifsson; Konstantinos K Tsilidis; arcOGEN Consortium; Nigel Arden; Nadim Aslam; Nicholas Bellamy; Fraser Birrell; Francisco J Blanco; Andrew Carr; Kay Chapman; Aaron G Day-Williams; Panos Deloukas; Michael Doherty; Gunnar Engström; Hafdis T Helgadottir; Albert Hofman; Thorvaldur Ingvarsson; Helgi Jonsson; Aime Keis; J Christiaan Keurentjes; Margreet Kloppenburg; Penelope A Lind; Andrew McCaskie; Nicholas G Martin; Lili Milani; Grant W Montgomery; Rob G H H Nelissen; Michael C Nevitt; Peter M Nilsson; William ER Ollier; Neeta Parimi; Ashok Rai; Stuart H Ralston; Mike R Reed; Jose A Riancho; Fernando Rivadeneira; Cristina Rodriguez-Fontenla; Lorraine Southam; Unnur Thorsteinsdottir; Aspasia Tsezou; Gillian A Wallis; J Mark Wilkinson; Antonio Gonzalez; Nancy E Lane; L Stefan Lohmander; John Loughlin; Andres Metspalu; Andre G Uitterlinden; Ingileif Jonsdottir; Kari Stefansson; P Eline Slagboom; Eleftheria Zeggini; Ingrid Meulenbelt; John PA Ioannidis; Tim D Spector; Joyce B J van Meurs; Ana M Valdes

doi:10.1136/annrheumdis-2012-203114

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Clinical and epidemiological research

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A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

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Evangelos Evangelou Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articles Google scholar articles
Hanneke J Kerkhof Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Unnur Styrkarsdottir Department of Population Genetics, deCODE Genetics, Reykjavik, Iceland PubMed articles Google scholar articles
Evangelia E Ntzani Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece PubMed articles Google scholar articles
Steffan D Bos Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Netherlands Consortium for Healthy Ageing, The Netherlands PubMed articles Google scholar articles
Tonu Esko Estonian Genome Center, University of Tartu, Tartu, Estonia Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia PubMed articles Google scholar articles
Daniel S Evans California Pacific Medical Center Research Institute, San Francisco, USA PubMed articles Google scholar articles
Sarah Metrustry Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articles Google scholar articles
Kalliope Panoutsopoulou Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK PubMed articles Google scholar articles
Yolande F M Ramos Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Gudmar Thorleifsson Department of Population Genetics, deCODE Genetics, Reykjavik, Iceland PubMed articles Google scholar articles
Konstantinos K Tsilidis Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece PubMed articles Google scholar articles
arcOGEN Consortium
Google scholar articles
Nigel Arden NIHR Biomedical Research Unit and ARUK Centre of excellence for Sport, Exercise and Osteoarthritis, University of Oxford, Oxford, UK MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK PubMed articles Google scholar articles
Nadim Aslam Worcestershire Royal Hospital, Worcestershire Acute Hospitals NHS Trust, Worcester, UK PubMed articles Google scholar articles
Nicholas Bellamy Centre of National Research on Disability and Rehabilitation Medicine, The University of Queensland, Brisbane, Australia PubMed articles Google scholar articles
Fraser Birrell Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK Wansbeck General Hospital, Northumbria Healthcare NHS Foundation Trust, Ashington, UK PubMed articles Google scholar articles
Francisco J Blanco Rheumatology Division, Instituto de Investigación Biomédica-Hospital Universitario A Coruña, A Corunna, Spain PubMed articles Google scholar articles
Andrew Carr NIHR Biomedical Research Unit and ARUK Centre of excellence for Sport, Exercise and Osteoarthritis, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Kay Chapman NIHR Biomedical Research Unit and ARUK Centre of excellence for Sport, Exercise and Osteoarthritis, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Aaron G Day-Williams Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK PubMed articles Google scholar articles
Panos Deloukas Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK PubMed articles Google scholar articles
Michael Doherty Department of Academic Rheumatology, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Gunnar Engström Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden PubMed articles Google scholar articles
Hafdis T Helgadottir Department of Population Genetics, deCODE Genetics, Reykjavik, Iceland PubMed articles Google scholar articles
Albert Hofman Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Thorvaldur Ingvarsson Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland School of Health Sciences, University of Akureyri, Akureyri, Iceland PubMed articles Google scholar articles
Helgi Jonsson Department of Medicine, The National University Hospital of Iceland, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Aime Keis Department of Public Health, University of Tartu, Tartu, Estonia Orthopedic Surgeons, Elva Hospital, Elva, Estonia PubMed articles Google scholar articles
J Christiaan Keurentjes Department of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Margreet Kloppenburg Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Penelope A Lind Department of Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia PubMed articles Google scholar articles
Andrew McCaskie Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Nicholas G Martin Department of Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia PubMed articles Google scholar articles
Lili Milani Estonian Genome Center, University of Tartu, Tartu, Estonia PubMed articles Google scholar articles
Grant W Montgomery Department of Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia PubMed articles Google scholar articles
Rob G H H Nelissen Department of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Michael C Nevitt Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Peter M Nilsson Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden PubMed articles Google scholar articles
William ER Ollier Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Neeta Parimi California Pacific Medical Center Research Institute, San Francisco, USA PubMed articles Google scholar articles
Ashok Rai Worcestershire Acute Hospitals NHS Trust, Worcester, UK PubMed articles Google scholar articles
Stuart H Ralston Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Mike R Reed Wansbeck General Hospital, Northumbria Healthcare NHS Foundation Trust, Ashington, UK PubMed articles Google scholar articles
Jose A Riancho Department of Internal Medicine, Hospital U.M. Valdecilla-IFIMAV, University of Cantabria, Santander, Spain PubMed articles Google scholar articles
Fernando Rivadeneira Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Cristina Rodriguez-Fontenla Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria—Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain PubMed articles Google scholar articles
Lorraine Southam Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK PubMed articles Google scholar articles
Unnur Thorsteinsdottir Department of Population Genetics, deCODE Genetics, Reykjavik, Iceland Department of Medicine, The National University Hospital of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Aspasia Tsezou Department of Biology, University of Thessaly, Medical School, Larissa, Greece PubMed articles Google scholar articles
Gillian A Wallis Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, UK PubMed articles Google scholar articles
J Mark Wilkinson Department of Human Metabolism, University of Sheffield, Sheffield, UK PubMed articles Google scholar articles
Antonio Gonzalez Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria—Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain PubMed articles Google scholar articles
Nancy E Lane Department of Medicine, University of California at Davis, Sacramento, USA PubMed articles Google scholar articles
L Stefan Lohmander Research Unit for Musculoskeletal Function and Physiotherapy, and Department of Orthopedics and Traumatology, University of Southern Denmark, Odense, Denmark Department of Clinical Sciences Lund, Lund University, Lund, Sweden PubMed articles Google scholar articles
John Loughlin Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Andres Metspalu Estonian Genome Center, University of Tartu, Tartu, Estonia Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia PubMed articles Google scholar articles
Andre G Uitterlinden Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Ingileif Jonsdottir Department of Population Genetics, deCODE Genetics, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
Kari Stefansson Department of Population Genetics, deCODE Genetics, Reykjavik, Iceland Faculty of Medicine, University of Iceland, Reykjavik, Iceland PubMed articles Google scholar articles
P Eline Slagboom Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Netherlands Consortium for Healthy Ageing, The Netherlands PubMed articles Google scholar articles
Eleftheria Zeggini Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK PubMed articles Google scholar articles
Ingrid Meulenbelt Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Netherlands Consortium for Healthy Ageing, The Netherlands PubMed articles Google scholar articles
John PA Ioannidis Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, USA PubMed articles Google scholar articles
Tim D Spector Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articles Google scholar articles
Joyce B J van Meurs Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Ana M Valdes Department of Twin Research & Genetic Epidemiology, King's College London, London, UK Department of Academic Rheumatology, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles

Correspondence to Dr Evangelos Evangelou, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece; vangelis{at}cc.uoi.gr and Dr Ana Valdes, Department of Academic Rheumatology, University of Nottingham, Nottingham, NG5 1PB, UK; Ana.Valdes{at}nottingham.ac.uk

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Citation

Evangelou E, Kerkhof HJ, Styrkarsdottir U, et al

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

Annals of the Rheumatic Diseases 2014;73:2130-2136.

Publication history

Received December 12, 2012
Accepted July 26, 2013
First published August 29, 2013.

Online issue publication

October 25, 2017

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