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Footnotes
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Contributors All authors contributed to the study design, data interpretation and the final manuscript. In addition, AMV and TN analysed and interpreted the data and prepared manuscript. AMV and TN supervised the study.
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Funding Supported by EC-FP7 programme grant 200 800 TREAT-OA and by a EULAR project grant to AMV (grant 108239). Dr. Neogi was supported by NIH AR055127. AstraZeneca UK funded the GOAL study sample and data collection. The TwinsUK cohort is supported by the Wellcome Trust. The HCS is supported by the Medical Research Council (UK) and the Oxford NIHR Musculoskeletal Biomedical Research Unit. The Framingham Osteoarthritis Study was funded by NIH AR47785 and AG18393 and the NHLBI N01-HC-25195. The Health, Aging and Body Composition Study was supported by NIA contracts N01AG62101, N01AG62103 and N01AG62106. The genome-wide association study was funded by NIA grant 1R01AG032098-01A1 to Wake Forest University Health Sciences and genotyping services were provided by the Centre for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the National Institutes of Health to The Johns Hopkins University, contract number HHSN268200782096C. The Tasmanian Older Adult Cohort collection was funded by the National Health and Medical Research Council of Australia, Arthritis Foundation of Australia; Tasmanian Community Fund and a University of Tasmania Grant-Institutional Research Scheme.
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Competing interests None.
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Ethics approval The appropriate ethics committee approved the study protocol of each of the contributing cohort studies included.
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Provenance and peer review Not commissioned; externally peer reviewed.