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Documentation of off-label use of biologics in Rheumatoid Arthritis
  1. Daniel E Furst,
  2. Roy Fleischman,
  3. Joachim Kalden,
  4. Arthur Kavanaugh,
  5. Joachim Sieper,
  6. Philip Mease,
  7. Josef Smolen,
  8. Ferrie Breedveld
  1. Los Angeles, California, USA
  1. Correspondence to Daniel E Furst, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA 90025, USA; gvaldivia{at}mednet.ucla.edu.

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Introduction

The ‘Updated Consensus Statement on Biological Agents for the Treatment of Rheumatic Diseases’ represents the consensus and efforts of a worldwide group of experts regarding the use of biologics in Rheumatoid Arthritis. That document details the use of biologics in registered uses for those drugs.

However, the biologic agents are used ‘off label’ in a very large array of other rheumatic diseases. To some degree, those uses are based on animal studies and mechanistic rationale but they often …

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