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AB0693 Is there a link between vitamin d and juvenile idiopathic arthritis?
  1. M. Nisar1,
  2. P. Cookson2,
  3. F. Masood2,
  4. A. Sansome3,
  5. A. Ostor1
  1. 1Rheumatology, CAMBRIDGE UNIVERSITY HOSPITALS
  2. 2School of Clinical Medicine, University of Cambridge
  3. 3Paediatrics, CAMBRIDGE UNIVERSITY HOSPITALS, Cambridge, United Kingdom

Abstract

Background Vitamin D (Vit D) insufficiency has been implicated in a number of autoimmune diseases. Its role in the pathogenesis of juvenile idiopathic arthritis (JIA) however is unclear including its relation to disease subtype and severity.

Objectives To establish a link between Vit D insufficiency and JIA

Methods We undertook a retrospective cohort study of Vit D levels in patients with a diagnosis of JIA. Demographic data, JIA subtype, medication use, comorbidities, disease severity, bone profile, inflammatory markers and autoantibody status were documented. Vit D levels were then correlated in each subgroup and with the other blood parameters. We predefined Vit D insufficiency as being <50 nmol/L.

Results In the 37 patients where Vit D levels were available, 34 (91.9%) were females, 22 white (59.9%) and the age groups were evenly split: 0-10 (n=13), 11-20 (n=12) and >21 years (n=12). The mean Vit D concentration was 49.6 nmol/L (range 13.2- 112.0 nmol/L). Seventeen patients (45.9%) had Vit D levels above 50nmol/l, 9 (24.3%) between 30 and 50 nmol/l, 10 (27.0%) between 15 and 30 nmol/l, and 1 patient (2.7%) had a serum concentration below 15 nmol/l. A trend for lower Vit D levels was seen in older patients. There were no significant differences in mean Vit D levels among various ethnicities or JIA subtypes however ESR and CRP were inversely related to Vit D concentrations. Vit D levels were significantly lower in patients who were not receiving methotrexate (MTX) (p=0.04 ) and in those receiving opioids (p=0.03).

Conclusions In our cohort half of patients with JIA have low Vit D levels which are inversely related to disease activity and disease duration. JIA subsets do not appear to have a direct association with Vit D however patients not receiving MTX had lower levels of Vit D. This study suggests that Vit D plays a role in JIA however further research is required to clarify its precise influence.

Disclosure of Interest None Declared

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