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AB0662 Frequencies of cognitive impairment and vitamin d deficiency and determination of apoe allells in the patients with fibromyalgia syndrome
  1. U. Bilge1,
  2. N. S. Yasar Bilge2,
  3. I. Unluoglu1,
  4. D. Ozbabalik3,
  5. M. Ipek1,
  6. T. Kasifoglu2,
  7. E. Gonullu2,
  8. C. Korkmaz2
  1. 1ESKISEHIR OSMANGAZI UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF FAMILY MEDICINE
  2. 2ESKISEHIR OSMANGAZI UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF RHEUMATOLOGY
  3. 3ESKISEHIR OSMANGAZI UNIVERSITY FACULTY OF MEDICINE DEPARTMENT OF NEUROLOGY, ESKISEHIR, Turkey

Abstract

Background Fibromyalgia syndrome (FMS) is a chronic musculoskeletal disorder. (1). Neurologic symptoms including memory decline, mental confusion and cognitive impairment have been frequently seen in FMS (2,3). There is a positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function and low levels of vitamin D were seen in fibromyalgia patients (4,5).

Objectives Our aim was to evaluate the levels of 25-OH-Vitamin D and cognitive functions and their relationships in patients with FMS.

Methods Montreal Cognitive Assessment (MOCA), Mini-Mental State Examination (MMSE) were performed for evaluation of cognitive functions and Vit-D levels were obtained. Scores lower than 26 were considered as cognitive impairment for both MOCA and MMSE. Magnetic resonance imaging findings and rates of single-nucleotide polymorphisms, 3 within the APOE gene (E2, E3, E4) were considered after neurological examination.

Results Forty patients (39 women, 1 man with a median age of 48.33±1.11) were enrolled in the study. Memory deterioration was found in 29 (%73) of patients. Cognitive dysfunction was found in %15 according to MMSE scores and %30 according to MOCA scores. A total of 18 MRI studies were performed and %56 of patients have positive findings. Nine of 18 patients have ischemic lesions according to MRI findings. A total of 29 patients’ APOE polymorphism were considered and one of them has ApoE2 allel, one of them has E4/E4 allel, 4 of them have Apo E3/E4 allel, and 21 of them have E3/E3 allels. Sixteen patients (%40) have Vitamin D deficiency. We did not find any correlations between cognitive test scores and Vitamin D levels.

Conclusions According to the study by Myers et al. ; the cumulative incidence of Alzheimer’s (AD) increased in a dose dependent fashion where 55% of the ApoE E4/E4 subjects developed AD by age 80, compared with 27% of the ApoE E3/E4 and 9% of the ApoE E3/E3 subjects by age 85 years (6). Prospective studies may be helpfull for the relationship between FMS, cognitive impairment and ApoE allels and vitamin D.

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Disclosure of Interest None Declared

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