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AB0660 Serum coenzyme-q10 activity and oxidative status in patients with fibromyalgia
  1. M. Bozkurt1,
  2. P. oktayoğlu1,
  3. D. uçar1,
  4. S. Em1,
  5. M. Caglayan1,
  6. H. yuksel2,
  7. I. Batmaz1,
  8. M. A. Sariyildiz1,
  9. K. Nas1
  1. 1Department of Physical Medicine and Rehabilitation
  2. 2 Faculty of Medicine, Dicle University, Diyarbakir, Turkey, diyarbakır, Turkey

Abstract

Objectives In this study, we aimed to show the relationship between CoQ10 and fatigue symptoms of Fibromyalgia (FM).

Methods A total of 40 patients diagnosed as primary FM according to the ACR criteria and 30 controls were included in the present study. All patients routine blood tests, erythrocyte sedimentation rate, total antioxidantstatus (TAS), total oxidativestatus (TOS) and Coenzyme Q10 (CoQ10) were evaluated. The patients were given the Fibromyalgia Impact Questionnaire (FIQ). Modified Fatigue Impact Scale (MFIS) weregiven in twogroupsandcompared.

Results The mean ages of the patients and the control groups were 36.09±8.87 and 34.44±6.25, respectively. The age difference was not statistically significant (P = 0.266). The mean time of diagnosis of FM patients was 2.88 years and their average number of tender points was 14. The serum CoQ10 levels were significantly lower in FM patients when compared to the healthy control group (p=0.004). The serum TOS levels were higher in the FM group than in the control group (P<0.05). The serum CoQ10 levels were negatively correlated with mean total score of MFIS (p=0.02, r=0.30), the mean scores for the ‘physical’ subscale of the MFIS (p=0.03, r=0.28), ‘cognitive’ (P = 0.02, r=0.30), VAS pain scores (p=0.00, r=0.38) and VAS fatigue scores (p=0.03, r=0.28).

Conclusions CoQ10 deficiency may be responsible for the etiopathogenesis of fatigue of FM. Serum Coenzyme Q10 may be a marker for diagnosis and follow-up of patients with FM.

Disclosure of Interest None Declared

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