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AB0655 Relationship between synaptosomal-associated protein 25 (snap-25) gene polymorphism and fibromyalgia syndrome
  1. A. Balkarli1,
  2. E. Tepeli2,
  3. H. Balkarlı3,
  4. V. Cobankara1
  1. 1Rheumatology
  2. 2Medical Genetics, Pamukkale University
  3. 3Orthopedics, Tavas Public Hospital, Denizli, Turkey

Abstract

Background SNAP-25 protein is a protein contributory to plasma membrane and synaptic vesicle fusions which is a critical point in neurotransmission. SNAP-25 gene is associated with personality disorders, behavioral symptoms and psychological disorders that can develop later in life. In addition, SNAP-25 protein can be related to different neurotransmitter functions because it is associated with vesicle membrane transition and fusion. This is important because neurologic, cognitive, psychologic disorders in fibromyalgia syndrome (FMS) can be related to this. Such relation will be enlightening for etiopathogenesis of FMS and treatment approaches.

Objectives We aimed to investigate SNAP-25 gene polymorphism and FMS relation in this prospective study.

Methods We included 71 patients who were diagnosed according to new criteria and 57 matched healthy women in this study. Both groups were evaluated in age, height, weight, BMI, education level, marital status and working conditions. FMS new diagnosis criteria scoring, sleep symptom scale, SF-36, Beck depression scale, BASDAI, VAS, revised fibromyalgia impact (FIQR) questionnaires were done to the patient group. SNAP-25 gene polymorphism and disease activity score correlations were compared.

Results Mean age was 38±5,196 and 38.12±4.939 in patient and control groups, respectively (p=0.542). No significant difference was found between groups in age, height, weight, BMI, education level, marital status and working condition (p>0,05). We determined MnlI T/G genotype in 34 (47.9%), MnlI G/G genotype in 7 (9.9%), Ddel T/C genotype in 40 (56.3%), and Ddel C/C genotype in 2 (2.8%) patients. 19 (33.3%) MnlI T/G genotype, 11 (19.3%) MnlI G/G genotype, 17 (29.8%) Ddel T/C genotype and 4 (7%) Ddel C/C genotypes were found in the control group. Ddel T/C genotype was significantly higher in the patient group (p=0,009). MnlI gene polymorphism did not show any correlation with any score whereas significant correlation was found between Ddel T/C genotype and lethargy score (p=0.042).

Conclusions FMS etiopathogenesis is not clearly known. Numerous neurologic, cognitive and psychological disorders were found during cause intended studies. Our study showed increased SNAP-25 Ddel T/C genotype which is related with personality disorders, behavioral symptoms and psychological disorders that can develop later in life in FMS patients when compared with the control group. However larger population is needed with temperament and character inventory in order to explain this relationship.

Disclosure of Interest None Declared

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