Background Osteoporosis is generalized bone disease characterized by disturbed bone strength, consequently fracture predisposition increases. One of the risk factors for osteoporotic fractures is the Body Mass Index (BMI) and it is evaluated according to the following criteria: malnutrition- to 18 kg/m2, normal body weight - 20-25 kg/m2, overweight - 25-30 kg/m2 and obesity - over 30 kg/m2.
Objectives To determine the significance of Body Mass Index for the effect of bisphosphonate therapy in women with newly diagnosed postmenopausal osteoporosis
Methods 92 women, with newly diagnosed postmenopausal osteoporosis, were included in this research. According to BMI values, the patients were divided into groups of under 18, 18 to 25, 25 to 30 and over 30 kg/m2. The groups were homogenous in relation to other risk factors for the appearance of osteoporosis. Bone mineral density (BMD) was measured with dual energy X-ray absorptiometry (DXA) on the Hologic Discovery machine before the therapy, as well as, 12 months after the bisphosphonate therapy.
Results T-score values and BMD during 12 month therapy with bisphosphonate the most increased in examinees whose BMI values were in the range of 25 to 30 kg/m2 (0,330±0,275), and the least in women with BMI below 18 (0,190±0,223), but ANOVA and Dante’s test did not confirm the existence of significant differences between all compared groups.
Conclusions Statistically significant difference in the effect of the bisphosphonate therapy was not found in postmenopausal women with newly diagnosed osteoporosis nor with different body mass index.
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Disclosure of Interest None Declared
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