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AB0592 Clinical and laboratory correlates of diabetes-induced knee osteoarthritis severity.
  1. E. P. Trifonova1,
  2. I. V. Shirinsky1,
  3. O. V. Sazonova2,
  4. V. S. Shirinsky1
  1. 1Siberian Branch of Russian Academy of Medical Sciences, Institute of Clinical Immunology
  2. 2The Novosibirsk City Diabetes Center, Novosibirsk, Russian Federation

Abstract

Background Recently, osteoarthritis (OA) has been shown to be a heterogeneous disease. Several OA phenotypes have been proposed, including post-traumatic, genetic, nodal generalized and metabolic OA. One of the possible phenotypes of OA is diabetes (type II) - associated osteoarthritis (T2D-associated OA). There is growing number of epidemiological and experimental data suggesting the presence of type II diabetes (T2D) associated OA. Raised glucose levels, proinflammatory cytokines, and adipose tissue may play a role in the pathogenesis of DM-associated OA. It can be hypothesized that this OA phenotype has a distinct set of biomarkers reflecting its peculiar pathogenesis features.

Objectives Our aim was to evaluate clinical and laboratory features of knee T2D-associated OA and to examine the association of anthropometric measures and serum cytokines levels with OA function and pain outcomes.

Methods Patients who participated in this study had bilateral knee OA according to ACR criteria and T2D diagnosed one year before the start of joint disease. We assessed serum cytokine (TNF-α, IL-6, IL-10) and glycated hemoglobin concentrations using ELISA, and liquid chromatography, respectively. We performed a correlation analysis investigating associations between laboratory data, anthropometric measures and pain, stiffness, physical function, quality of life as reported by participants using an interview-lead questionnaire (Knee injury and Osteoarthritis Outcome Score - KOOS, Western Ontario and McMaster Universities Arthritis Index – WOMAC, VAS scale). Correlation was assessed using Spearman correlation coefficient (rs).

Results Fifty three participants were examined, median age was 63 (interquartile range (IQR): 58, 25-69). Forty four were women (84.12%) with median body mass index (BMI) 34.35 (IQR: 31.98-39.78) and eleven were men (15.87%) with median BMI 31.11 (IQR: 26.89-35.23). Significant correlation was found beween waist circumference (WC), BMI and most of pain and function outcomes measures (Table). Serum cytokines concentrations and HbA1c were not correlated with OA severity measures.

Conclusions This study suggests that waist circumference and BMI are linked with the severity of knee T2D-associated OA. The correlation between serum cytokines concentrations and OA pain and function measures was not observed. A positive association between waist circumference and T2D-associated OA may suppose a role of adipose tissue derived factors in this OA phenotype. These data should be verified by larger studies.

Disclosure of Interest None Declared

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