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AB0567 Coexistence of spondyloarthropathy and hypermobility joint syndrome: a report of seven cases
  1. V. Ognenovski1,
  2. S. Stewart1
  1. 1Division of Rheumatology, University of Michigan, Ann Arbor, United States


Background Spondyloarthropathies manifest with axial skeletal pain, stiffness and loss of mobility, whereas, Hypermobility Joint Syndromes, most commonly Benign Joint Hypermobility Syndrome (BJHS), Marfan’s syndrome, and Ehler’s Danlos syndrome (EDS), manifest with increased joint laxity and mobility in the peripheral and axial skeleton, and peripheral joint and back pain. The presence of hypermobility in patients with spondyloarthropathy, may underestimate the severity of spinal loss of mobility and present a diagnostic dilemma.

Objectives To report the unusual association of Spondyloarthropathy( SpA) and Hypermobility Joint Syndrome(HJS).

Methods Seven patients presenting in an academic rheumatology clinic over a course of 15 years are described in the following table

Conclusions Peripheral arthralgia and back pain are common symptoms of hypermobility syndrome (1). Previously there have been four case reports of coexistence of SpA with HJS (2,3,4,5). We are presenting the largest series of SpA cases coexisting with Hypermobility syndromes. The unique association of two pathophysiologically(clinically) opposite entities may prevent more severe manifestation of axial stiffness and loss of mobility in SpA, a potentially beneficial effect. However, back pain persisted as a dominant symptom. This association should be suspected in young patients with back pain and physical exam findings of peripheral joint hypermobility and axial skeletal loss of mobility.

  1. Kirk JA, et al. Ann Rheum Dis 1967; 26:419.

  2. Fietta P, Clin Rheumatol. 2001;20(2):140-2.

  3. Viitanen JV.Scand J Rheumatol. 1999;28(2):120-2.

  4. LeBlanc ML, et al. Arthritis Rheum. 1980 Jan;23(1):129-31.

  5. Vounotrypidis, P. Medical Hyptheses 75 (2010) pp 284-286.

Disclosure of Interest None Declared

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