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AB0522 Effect of first-line anti-tnf therapy on health related quality of life in patients with ankylosing spondylitis - results from the czech biologics registry attra
  1. S. Forejtova1,
  2. J. Závada1,
  3. K. Jarosova1,
  4. M. Uher2,
  5. K. Hejduk2,
  6. K. Pavelka1,
  7. J. Vencovsky1
  1. 1Institute of Rheumatology, Prague
  2. 2Institute of Biostatistics and Analysis, Masarky University, Brno, Czech Republic

Abstract

Objectives The aim of this study was to describe changes in the Medical Outcomes Study Short Form-36 (SF-36) physical (PCS) and mental (MCS) component summary and domain scores for ankylosing spondylitis (AS) patients enrolled in the ATTRA registry and completing one year of the first-line anti-TNF therapy., SF-36 domain scores of AS patients before and after one year of anti-TNF therapy were compared with age-standardized normative values of the general Czech population.

Methods Only AS patients with available clinical (BASDAI, HAQ) and HRQOL (SF-36) data completing one year of anti-TNF treatment were included in the analyses. Paired Wilcoxon test was used to compare changes in continuous variables with baseline levels. One- sample T test was used to compare age-standardized mean domain scores of AS patients with reportedCzech normative values [1]. Numbers are median (5%>95% percentile) if not stated otherwise

Results 535 AS patients with available required data and completing one year of the first-line anti-TNF therapy were identified. In the analyzed sample there were 74% of males, with median age of 37 years (25-75) and median disease duration of 5 years (0-22) at the start of anti-TNF therapy. 23%, 35% and 43%of patients were treated with infliximab, adalimumab, and etanercept, respectively. PCS scores improved from 29 (11-62) to 58 (26-85) at W12 (p<0.001) and to 64 (26-91) at W54 (p<0.001). MCS scores improved from 43 (17-75) to 66 (31-87) at W12 (p<0.001) and to 70 (31-91) at W54 (p<0.001).

Conclusions In this cohort of AS patients completing one year of the first-line anti-TNF therapy clinically meaningful and statistically significant improvements were observed in all SF-36 domains. In 4 domains (vitality, social functioning, role emotional, and mental health) the AS patients reached normative values of the Czech general population.

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  1. Sobotník Z. [Experiences with the application of preliminary Czech version of the questionary SF36]. Zdravotnictví v ČR 1 – 2 / 1998, str. 50 – 54

Acknowledgements Supported by project 00023728 from Ministry of Health in the Czech Republic

Disclosure of Interest None Declared

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