Objectives To find the determinants of pulse wave velocity (PWV) and evaluate the association between degree of capillary microscopic changes and PWV in systemic sclerosis (SSc) patients.
Methods Forty-five systemic sclerosis patients were enrolled. Traditional cardiovascular risk factors, SSc activity/severity markers, hemodynamic factors and microscopic capillaroscopic findings were obtained. Aortic PWV was measured using sequential recordings of the arterial pressure wave at the carotid and femoral arteries.
Results Most of SSc patients showed low traditional cardiovascular risk factors. Simple and multiple regression analysis showed that radial systolic blood pressure is only a risk factor for increased PWV value in SSc patients. The radial and aortic systolic blood pressure, PWV levels significantly increased with progression of nailfold capillary microscopy changes (p-value = 0.019, 0.020, 0.018, respectively). However, after analysis of covariance using radial and aortic systolic blood pressure as the covariate, it was statistically not significant in PWV levels between early and advanced (active and late) capillary groups (adjusted p-value = 0.526, Table 1).
Conclusions Radial systolic blood pressure, not the microscopic capillary changes, is the most important factor of arterial stiffness in systemic sclerosis patients.
Disclosure of Interest None Declared