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AB0483 Causes of hospitalisation in behcet’s syndrome over a ten-year period
  1. Y. Ozguler1,
  2. A. S. Pala1,
  3. V. Hamuryudan1,
  4. G. Hatemi1,
  5. S. Yurdakul1,
  6. H. Yazici1
  1. 1Rheumatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

Abstract

Objectives We are unaware of previous studies on hospitalisation in Behçet’s syndrome (BS). We surveyed the causes and outcome of hospitalisations among BS patients in a dedicated center.

Methods We surveyed the records of all hospitalisations in our clinic between 2002-2011 to identify patients with a diagnosis of BS. We reviewed both the inpatient and outpatient charts of all BS patients who were hospitalised to identify the demographic and clinical features, causes of hospitalisation and outcome. We tried to contact the patients to determine their current condition.

Results 178 BS patients (74% men, mean age 42.9±11.3) had been hospitalized for a total of 211 times during the last ten years. We were able to contact 104(58%) of them. The reasons for hospitalisation were directly related to BS organ involvement in 118(56%) and to complications in 93(44%). The most common BS related reasons were vascular involvement in 74/118(63%) (including 21 patients with pulmonary artery aneurysms, 10 with peripheral artery aneurysms and 11 with serious venous thrombosis such as vena cava superior and Budd-Chiari syndrome), neurologic involvement in 14/118(12%), gastrointestinal involvement in 6/118(5%) and eye involvement in 6/118(5%). Hospitalisations caused by complications of BS were infections in 39/93(42%), and other drug related adverse events in 15/93(16%). Neoplasias were diagnosed in 5 patients. Among the 178 patients, 16(9%) had died. Most common causes of death were vascular involvement (n=5), infections (n=4) and malignancies (n=4).

Conclusions Vascular involvement is the leading cause of hospitalisation among BS patients, followed by infections related to therapy. Adverse events related to immunosuppressives are problematic. The predominance of men among hospitalized patients underlines the more severe course of BS in this sex. The relatively low frequency of gastrointestinal involvement among hospitalisations is in line with our previous observation that this type of involvement is rare in our BS patients.

Disclosure of Interest None Declared

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