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AB0475 Vitamin d status analysis in behçet syndrome patients. a case-control study
  1. M. Kechida1,
  2. O. Harzallah1,
  3. I. Hellara2,
  4. R. Klii1,
  5. F. Najjar2,
  6. S. Mahjoub1
  1. 1Internal Medicine Department
  2. 2Chemistry Department, Fattouma Bourguiba Hospital, Monastir, Tunisia

Abstract

Background Vitamin D has newly well-proven immunomodulatory effects (1, 2). This vitamin inhibits TH1 proliferation and cytokine’s production and activates TH2 functions. It also regulates toll like receptors expression on blood monocytes surface (3). Behçet’s syndrome (BS) is a chronic multisystem inflammatory disease which would be due, in genetically predisposed patients, to an abnormal T cell (TH1) activation in response to environmental and/or endogenous stimuli of the innate immune system via TLR. Few studies focused on vitamin D role in BS.

Objectives The aim of our work was to analyze vitamin D status in BS patients.

Methods Vitamin D status was analyzed in 40 BS patients (mean age: 37.5 years, sex ratio: 1.85) in comparison to age and sex matched 40 healthy controls. Patients under steroids and/or calcium and vitamin D were excluded. Vitamin D deficiency was defined by a 25(OH)D3 level below 10 ng/ml. A level above 30ng/ml was considered as normal. 25(0H)D3 level was measured by electrochemiluminescence.

Results 25 (0H)D3 mean level was at 14,64 ng/ml (3 – 44,29ng/ml). A vitamin D deficiency was attested in 14/40 cases (35%). 25 (0H)D3 level was normal in only 2 patients. However, there wasn’t any difference between 25(0H)D3 levels in BS patients and healthy controls. Comparison between main demographic and biological characteristics of the two groups is summarized in table 1.

Conclusions Nearly 1/3 of BS patients have a vitamin D deficiency. However there wasn’t any difference between 25(0H)D3 levels in patients and controls. Few studies (4, 5) focused on vitamin D status in BS and their results are controversial. Other studies with larger samples are required.

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  3. Sadeghi K, Wessner B, Laggner U et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular pattern. Eur J Immunol 2006; 36:361–70

  4. Do JE, Kwon SY, Park S et al. Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behçet’s disease. Rheumatology 2008; 47: 840–48

  5. Karatay S, Yildirim K, Karakuzu A. Vitamin D status in patients with Behcet’s Disease. CLINICS 2011; 66(5):721- 3

Disclosure of Interest None Declared

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